非布索坦的使用量多少呢？

Inhibits uric acid production by inhibiting xanthine oxidase (XO). Allopurinol can inhibit the reduced form of XO, while febuxostat has a good inhibitory effect on both the reduced and oxidized forms, so its uric acid-lowering effect is more powerful and faster. Febuxostat was developed in Japan in 2004, and was approved for marketing by European EMEA in 2008, the US FDA in 2009, and the State Food and Drug Administration of China in 2013. Today let’s find out how much febuxostat should be used?

The recommended oral dose of febuxostat tablets is 40 mg or 80 mg once daily. The recommended starting dose of febuxostat tablets is 40 mg once daily. If the blood uric acid level is still not less than 6 mg/dl (approximately 360 μmol/L) after 2 weeks, it is recommended that the dose be increased to 80 mg once a day.

Febuxostat was started at 10 mg/day for 2 weeks, then increased to 20 mg/day for 4 weeks, then to 40 mg/day. Starting with a low dose and gradually increasing the dose can prevent acute gout attacks caused by initial changes in blood uric acid levels. Treat with febuxostat 40 mg/day for 6 months, and review uric acid levels regularly. Generally, it takes 6 months to clean up excess blood uric acid in the body. 

After 6 months of treatment:

(1) If the serum uric acid level remains between 240 umol/l and 360 umol/l, maintain febuxostat 40 mg/day treatment. 

(2) If the blood uric acid level is higher than 360 umol/l, increase the dose of fexostatin by 60 mg/day, up to a maximum of 80 mg/day, and monitor blood uric acid, liver and kidney function regularly.

  (3) If the blood uric acid level is lower than 240 umol/l, the dose of febuxostat can be reduced to 20 mg/day and the treatment can be maintained for 6 months.

However, during use, you need to pay attention to the following: In the early stages of taking febuxostat, the frequency of gout attacks often increases. This is caused by a decrease in blood uric acid concentration, which leads to the activity of urate deposits in tissues. To prevent gout attacks during the initial stages of treatment, it is recommended to take nonsteroidal anti-inflammatory drugs or colchicine at the same time. If gout attacks during treatment with febuxostat, there is no need to discontinue treatment with febuxostat. Gout should be treated accordingly according to the patient's specific situation. Contraindications for the use of Febuxostat tablets: This product is contraindicated in patients receiving azathioprine and mercaptopurine treatment. In addition, you need to follow your doctor’s instructions carefully.

The above is the dosage content, I hope it can help you!