非布索坦治疗痛风效果怎么样呢？

For the treatment of chronic hyperuricemia (gout). Gout occurs because the body produces excessive blood uric acid and the kidneys' reduced ability to eliminate it. Blood uric acid accumulates in the body, causing urate crystals to accumulate in joints and internal organs.

Febuxostat also has unique advantages over other drugs. Allopurinol only has an inhibitory effect on the reduced form of XOR, while febuxostat has a significant inhibitory effect on both air-oxidized and reduced forms of XOR, so its cholesterol-lowering effect is more powerful and long-lasting. And there is better security.

The successful development of febuxostat is good news for many gout patients. What patients are more concerned about is the effect of febuxostat in treating gout. So how effective is febuxostat in treating gout? Is the effect really good?

In a phase III clinical trial, researchers compared the efficacy of febuxostat (80 and 120 mg/d) and allopurinol (300 mg/d) in parallel. A 1-year study of 760 patients showed that compared with the allopurinol group, more patients in the febuxostat group achieved the main trial efficacy indicator - the sUA concentration was measured below 60 mg/L in the last 3 months (all subjects were gout patients, and the sUA concentration before the trial was above 80 mg/L).

After 52 weeks of treatment, febuxostat failed to significantly reduce the area of tophi, but the effect was more obvious in the high-dose group in the early stages of the trial. In each treatment group, patients with sUA concentrations reaching the target (<60 mg/L) were less likely to have gout attacks, and their tophi area was more significantly reduced. Adverse reactions and their incidence rates were similar in each treatment group. Adverse reactions included abnormal liver function, diarrhea, headache, joint-related signs and symptoms, and musculoskeletal/connective tissue symptoms.

According to clinical trial data, the effect of febuxostat in the treatment of gout is very obvious. Patients can use the medication correctly according to the doctor’s diagnosis and treatment recommendations. In addition, if patients have other questions (such as drug prices, purchasing channels), they can consult Medical Companion Travel.