非布索坦对痛风有效果吗？

Is it effective against gout? Is this drug really effective in treating gout? Febuxostat is the latest XOR inhibitor developed in the world. Febuxostat acts highly selectively on this oxidase, thereby reducing uric acid synthesis in the body and lowering uric acid concentration, so it can effectively treat ventilation diseases. Gout occurs due to excessive production of uric acid in the body and reduced kidney clearance. Uric acid continues to accumulate in the body, eventually leading to the deposition of urate crystals in joints and various organs. For this reason, the usual methods used to treat gout are: promoting uric acid excretion and inhibiting uric acid production, and taking appropriate measures to improve related symptoms.

The development of Febuxostat has effectively alleviated the pain of gout patients. And the drug is safer. The safety and efficacy of febuxostat in gout were evaluated in a multicenter, double-blind, randomized phase II clinical study. A total of 136 men and 17 women with gout were randomized to receive placebo or febuxostat (40, 80, or 120 mg/d).

After 4 weeks of treatment, it was found that the serum uric acid concentration of patients in each dose group of febuxostat was significantly reduced compared to before treatment, with an average reduction of 37%, 44% and 59% in each group from low to high dose, while patients in the placebo group only decreased by 2%. The vast majority of patients persisted in completing the trial. The incidence of adverse reactions in the febuxostat and placebo groups was similar, and most of these adverse reactions were mild symptoms. The most common ones were diarrhea, pain, back pain, headache and joint pain.

Febuxostat tablets are suitable for the long-term treatment of hyperuricemia in gout patients. Therefore, if gout patients develop hyperuricemia, they can be treated with Febuxostat tablets for a long time, which will have a more prominent therapeutic effect. However, patients must strictly follow the doctor's instructions during the medication and cannot blindly use this drug for treatment. Although febuxostat has a relatively good therapeutic effect and is relatively safe, if the patient uses it excessively for a long time, it may also cause some intolerable side effects. Therefore, during the period of taking it, patients must strictly follow the doctor's instructions and pay more attention to their own physical changes.