用非布索坦治疗期间要注意什么？

Gout attacks often increase in the frequency of gout attacks in the early stages of taking the drug. It is recommended that patients take concomitant nonsteroidal anti-inflammatory drugs or colchicine.

Gout is actually called hyperuricemia in traditional Chinese medicine. Western medicine generally calls it hyperuricemia. Gout is a painful joint disease caused by high uric acid. Uric acid is a metabolic product that is slightly soluble in water and easily forms crystals. The human body produces uric acid every day, and then excretes it through the body's liver, kidneys, feces and sweat. The formation of gout is because uric acid cannot be eliminated from the body and continues to accumulate in the body.

So what are the precautions for taking febuxostat? What should I pay attention to during treatment with febuxostat?

During treatment with febuxostat, if the patient's ALT exceeds more than 3 times the upper limit of the reference range, the drug should be discontinued. If the patient's ALT exceeds more than 3 times the reference range, and the patient's serum total bilirubin exceeds more than 2 times the reference range, and other causes of the disease are excluded, it indicates that the patient is at risk of severe drug-induced liver damage. If patients experience severe discomfort during medication, they should seek medical attention immediately and use the medication correctly according to the doctor's diagnosis and treatment recommendations. They should not use medication blindly.

Not only that, in randomized controlled trials, it was found that compared with allopurinol, patients taking febuxostat for the treatment of gout had a higher probability of cardiovascular thrombotic events (including cardiovascular death, non-fatal myocardial infarction, non-fatal stroke), with febuxostat being 0.74/100 patient-years (95% CI: 0.36-1.37) and allopurinol being 0.60/100 patient-years (95% CI: 0.16-1.53). A direct relationship between febuxostat and cardiovascular thrombotic events cannot be determined at this time. However, patients should pay attention to monitor the symptoms and signs of myocardial infarction and stroke when taking the drug. Patients should pay attention to their physical changes while taking febuxostat and take medication strictly in accordance with the doctor's instructions.

The above are the things that should be paid attention to when taking it. If the patient has any other questions, he or she can consult the medical companion service.