非布司他（非布索坦）获批适应症

Approved indications for febuxostat: febuxostat (febuxostat) is suitable for the long-term treatment of hyperuricemia combined with gout, including gout patients with increased uric acid production and decreased renal clearance. It is especially suitable for gout patients who are intolerant or contraindicated by allopurinol and whose uric acid cannot reach the target after allopurinol treatment. However, febuxostat is not recommended for the treatment of asymptomatic hyperuricemia.

Febuxostat (febuxostat, feburic) works by reducing blood urate concentration. It is completely absorbed after oral administration and has a high utilization rate. Food and antacids have no significant effect on its absorption. Unlike allopurinol, its structure is a non-purine analogue, so it is selective in inhibiting xanthine oxidase and has little effect on other enzymes in purine or pyrimidine metabolism. This means that febuxostat (febuxostat) is less likely to be affected by other factors and has a stable effect.

The advantages of febuxostat (febuxostat, feburic) in the treatment of gout: 1. Few patients experience allergic reactions. Some patients will develop allergic reactions such as rash and itching after taking allopurinol. For a very small number of patients, such allergic reactions may be fatal. Therefore, febuxostat may be the first choice for patients who are allergic to allopurinol. 2. For patients with renal insufficiency (for example, if your creatinine is very high), the dose may need to be adjusted according to the condition of the kidneys when using allopurinol. Since febuxostat is metabolized by the liver, there is no problem of adjusting the dose, so it is more convenient. 3. Generally, one tablet a day saves trouble. 4. The effect of lowering uric acid is significant. The effect of one tablet of febuxostat (feburic) is similar to that of three tablets of allopurinol.

Febuxostat (febuxostat, feburic) is a very good uric acid-lowering drug. The most important thing in the treatment of gout is long-term persistence. Long-term control can be achieved based on lifestyle adjustments and supplemented by drug treatment.