feburic治疗痛风疗效怎么样？

feburic (febuxostat) is a new generation of xanthine oxidase inhibitor developed by Teijin Corporation of Japan and is clinically used to treat hyperuricemia (gout). Purine nucleotides in food are mainly oxidized to uric acid in two steps by xanthine oxidase. Feburic is a new and highly efficient non-purine xanthine oxidase selective inhibitor that can directly inhibit the activity of xanthine oxidase and reduce the production of uric acid.

The production of uric acid in the body is related to purine metabolism. In the final step of purine metabolism, hypoxanthine generates xanthine under the action of xanthine oxidoreductase (XOR), and then further generates uric acid. Inhibiting the activity of this enzyme can effectively reduce the production of uric acid. By acting highly selectively on this oxidase, feburic reduces the synthesis of uric acid in the body and lowers the concentration of uric acid, thereby effectively treating gout.

How effective is feburic in treating gout?

In a phase III clinical trial, the efficacy of allopurinol (300 mg/d) and feburic (80 and 120 mg/d) were compared. The study lasted for one year, and a total of 760 patients were included. All subjects were gout patients, and the sUA concentration before the trial was above 80mg/L.

The feburic (febuxostat) group had a relatively good effect during treatment. Compared with the allopurinol group, more patients reached the main trial efficacy index - the sUA concentration was measured below 60mg/L in the last 3 months; after 52 weeks of treatment, feburic failed to significantly reduce Tophi area (tophi is an aggregate of urate crystals unique to gout), but in the high-dose group early in the trial, this effect was more obvious; in each treatment group, patients with sUA concentration reaching the target (<60mg/L) were less likely to have gout attacks again, and their tophi area was more significantly reduced.

feburic (febuxostat) has a significant effect in the treatment of gout, and as a new drug, feburic has a more powerful and long-lasting effect in reducing uric acid, making it a good choice for gout patients.