feburic的用法与用量

feburic (febuxostat, febuxostat) was approved for marketing in the United States in 2009. Its main component is febuxostat, which can selectively bind XO and does not interact with other enzymes in the metabolism of purine and pyrimidine (such as purine nucleoside phosphorylase, etc.), nor will it affect the metabolism of pyrimidine and purine. It is suitable for the long-term treatment of hyperuricemia with gout symptoms.

Although feburic has been on the market in my country for several years, it is still relatively unfamiliar to many newly diagnosed patients taking the drug. Let’s take a look at the usage and dosage of feburic.

The starting doses of feburic can be 40mg/day and 80mg/day, with the 80mg dose being more effective for severe patients. If the serum uric acid level is still higher than 6 mg/dL after taking 40 mg/day for 2 weeks, you can take 80 mg/day. Note: Domestic and foreign diagnosis and treatment guidelines do not recommend routine drug uric acid-lowering treatment for asymptomatic hyperuricemia, and patients should not use drugs arbitrarily.

Use in Special Populations: The safety and effectiveness of feburic in patients under 18 years of age have not been established. Elderly patients do not need to adjust the dosage, but it cannot be ruled out that some elderly patients are more sensitive to this product. It is not known whether feburic is excreted in human milk. Since many drugs can be secreted into breast milk, lactating women should use feburic with caution to avoid harm to the baby.

When feburic is used alone, it is easy to cause an acute attack of gout, so colchicine or nonsteroidal anti-inflammatory drugs must be added under the guidance of a doctor during the first 3 to 6 months of use.

Common side effects of feburic (febuxostat, febuxostat) include abnormal liver function, nausea, joint pain, rash, diarrhea and dizziness, among which abnormal liver function is a serious adverse reaction. Other side effects include upper respiratory tract infection, muscle and skeletal muscle and related tissue abnormalities, headache, edema, pulmonary infection, paresthesia and hypoesthesia, etc.