feburic作用及价格

The main ingredient of feburic (febuxostat, febuxostat) is febuxostat, which is a xanthine oxidase (XO) inhibitor and is suitable for the long-term treatment of hyperuricemia with gout symptoms. The latest feburic tablets to enter China were approved by the State Food and Drug Administration for listing in the Chinese market on September 4, 2018.

Let's first understand the role of feburic.

The molybdopterin center is an extremely critical site in the process of generating uric acid from xanthine. feburic (febuxostat, febuxostat) can treat gout by tightly binding to the central active site of XO molybdopterin, so that the oxidized or reduced molybdenum cofactor remains in an isolated state, thereby inhibiting the collection of XO and substrates, reducing the formation of uric acid, and lowering the level of uric acid in the blood.

Unlike allopurinol, the feburic structure is a non-purine analog, so it will selectively bind XO and will not interact with other enzymes in the metabolism of purine and pyrimidine (such as purine nucleoside phosphorylase, etc.), nor will it affect the metabolism of pyrimidine and purine. The "China Guidelines for the Diagnosis and Treatment of Hyperuricemia and Gout (2019)" recommends feburic (febuxostat, febuxostat) as the first-line drug for lowering uric acid in patients with gout.

There is no doubt about the effectiveness of feburic, but what is its price?

We learned that the price of the original feburic drug in Japan is higher than that in India, about $1,500 per box. feburic (febuxostat, febuxostat) produced by Zydus Pharmaceuticals in India has the same efficacy as the original drug, but the price is indeed much lower. The specification is 80mg*30 tablets/box. Its price is around 200$. Due to the floating exchange rate, the price cannot be accurate. For specific prices and purchasing information, please consult the regular overseas medical service company Medical Travel.