非布司他治疗痛风的效果好吗？

Febuxostat (Febuxostat) is a tablet drug that is administered orally. The recommended initial dose is 40 mg once a day. If serum uric acid <6 mg/dL is not achieved, it can be increased to 80 mg once a day after 2 weeks. This product is not recommended for the treatment of asymptomatic hyperuricemia.

On September 4, 2018, Febuxostat was approved by the National Medical Products Administration to be launched on the Chinese market. Gout is caused by the accumulation of uric acid in the body due to the excessive production of uric acid in the body and the reduced ability of the kidneys to remove it, resulting in the deposition of urate crystals in joints and various organs. Currently commonly used clinical uric acid-lowering drugs include drugs that inhibit uric acid production and drugs that promote uric acid excretion. Febuxostat (Febuxostat) is a drug that inhibits uric acid production and can directly inhibit the activity of xanthine oxidase and reduce the production of uric acid.

The effectiveness of febuxostat has been confirmed in clinical trials. The effectiveness of febuxostat in the general population is about 70%, which is higher than that of allopurinol. and significantly higher than the placebo group. Clinical trial data on more than 3,000 people show that febuxostat (Febuxostat) can effectively reduce uric acid in the blood to 360 μmol/L after taking the drug for six months.

In one trial, 153 patients (136 men and 17 women) were randomized to receive placebo or febuxostat (40, 80, or 120 mg/day).

The test results after 4 weeks showed that the serum uric acid concentration of patients in each dose group of febuxostat (Febuxostat) was significantly reduced compared with before treatment. According to the dose, each group decreased by an average of 37%, 44% and 59% respectively, while the patients in the placebo group only decreased by 2%. In other words, the use of febuxostat can effectively reduce the patient's serum uric acid concentration and achieve the effect of treating gout.

Febuxostat is very effective in treating gout. In addition to my country, India has also launched its generic drugs. If patients need to purchase it, they can consult their medical companions.