非布司他对痛风能有多大疗效？

Febuxostat is indicated for the long-term treatment of hyperuricemia with symptoms of gout, but is not recommended for the treatment of asymptomatic hyperuricemia. In 2009, Febuxostat was approved by the US FDA for marketing, and it was not approved for marketing in my country until September 2018. This is also a new drug for the treatment of gout.

Febuxostat is a tablet, available in two specifications: 40mg/tablet and 80mg/tablet. Usually, the initial recommended dose for patients is 40 mg/day, administered orally. If the symptoms are severe, it can be adjusted to 80 mg/day; if the serum uric acid level is still higher than 6 mg/dL after 2 weeks of taking 40 mg/day, the dose can be increased to 80 mg/day.

Many patients who don't understand febuxostat can't help but ask: How effective can febuxostat be for gout?

The safety and efficacy of febuxostat (febuxostat) in gout were evaluated based on a multicenter, double-blind, randomized phase II clinical study. A total of 136 male and 17 female gout patients were randomly assigned to receive placebo or febuxostat (40, 80 or 120 mg/d). After 4 weeks, tests found that the serum uric acid concentration of patients in each dose group of febuxostat (febuxostat) was significantly lower than before treatment, with an average reduction of 37%, 44% and 59% in each group from low to high dose, while patients in the placebo group only decreased by 2%. The effect of febuxostat was significantly better than that of the placebo group.

The vast majority of patients in the trial persisted in completing the trial. The incidence of adverse reactions in the febuxostat (Febuxostat) and placebo groups was similar, and most of these adverse reactions were mild and self-limiting. Common ones included diarrhea, pain, back pain, headache and joint pain.

Febuxostat (Febuxostat) has a significant effect in the treatment of gout. As a new drug, compared with allopurinol, Febuxostat has a more powerful and lasting effect in reducing uric acid, has fewer side effects and is highly safe. It is a good choice for gout patients.