地拉罗司要注意什么事项呢？

It is a ligand with three protrusions. Although the affinity of deferasirox dispersible tablets to zinc and copper is very low, the concentrations of these trace metals in the serum still decreased to varying degrees after administration. The tolerability and safety of deferasirox are relatively good among similar drugs. Today let’s take a look at what should we pay attention to when taking deferasirox?

It is recommended that patients with iron accumulation should pay attention when taking deferasirox, such as those who require long-term blood transfusion (blood transfusion volume up to 100 ml/kg) and whose serum ferritin exceeds 1000 μg/l. According to the body weight, it is recommended to take 20 mg/kg daily at the initial stage. Deferasirox, depending on the serum ferritin index, patients may need to adjust or increase the dose of deferasirox. Generally, the dose will be increased in units of 5 mg/kg or 10 mg/kg, but the total dose should not exceed 30 mg/kg per day.

Precautions when taking deferasirox: Deferasirox may cause rash. Generally, the rash will disappear automatically without the need to adjust the dose or stop the medication; if the condition is serious or persistent, the medication should be stopped. The patient's vision or hearing may be affected. It should be taken 30 minutes before meals. It should be taken at the same time every day. Deferasirox should not be taken with aluminum-containing drugs (such as gastric acid neutralizers).

Common adverse reactions of taking deferasirox: diarrhea, vomiting, headache, abdominal pain, fever, rash, increased serum creatinine, etc. Other adverse reactions: increased liver enzymes, cough, throat inflammation, urticaria. While taking medicine, patients with thalassemia are often physically weak, so they should live cautiously in daily life, adapt to cold temperatures, and pay attention to preventing external infections; engage in more outdoor activities; breathe fresh air; and perform appropriate physical exercises, Qigong exercises, Tai Chi, etc. to enhance physical fitness and disease resistance.

When taking deferasirox, the common starting dose is 20 mg/(kg·d). If there is a large amount of blood transfusion and the iron increase is >0.5 mg/(kg·d) or the iron load before treatment is high, the recommended dose is 30 mg/(kg·d). If the iron increase is <0.3 mg/kg, 10-15 mg/kg/d is enough to control the condition. Administer on an empty stomach 30 minutes before meals and should be completely dissolved in water or apple or orange juice. Lower doses of deferasirox [5-10 mg/(kg·d)] can only be used in young patients with mild iron overload and few blood transfusions, or in elderly patients who have not received satisfactory results from chelation therapy in the past; patients using deferasirox 20 and 30 mg/(kg·d) need to carefully monitor body iron stores, because body iron levels may continue to rise in 50% and 10% of patients. In addition, the frequency of blood transfusion can also affect the effect of deferasirox in controlling liver concentration. When the iron intake is greater than 0.5 mg/(kg·d), only 47% of patients who receive the same dose of deferasirox have a reduction in liver concentration.

The above is the content of the precautions, I hope it can help you!