地拉罗司治疗铁质积聚的效果如何？

Dispersible tablets can be used for patients with iron accumulation due to long-term blood transfusion (such as thalassemia or other rare anemias), and are suitable for children over two years old and adults. Corresponding to body weight, it is initially recommended to take deferasirox at a daily dose of 20 mg/kg, depending on the improvement of serum ferritin indicators. Usage and dosage are based on the patient's personal condition, constitution, family genetic history, and drug ingredients. The drug is accurately selected to truly prescribe the right medicine for the disease. At the same time, the medicine is accurately administered in the appropriate method, appropriate dose, and appropriate time. Today we will take a look at the effect of deferasirox in treating iron accumulation?

More importantly, the benefits of iron removal therapy are not only reflected in the reduction of ferritin levels, but can also improve the patient's hematological response, stabilize and reverse the patient's liver fibrosis, improve the heart's ejection fraction, and prevent the occurrence of important cardiac events such as heart failure and arrhythmia. my country's data also supports the above conclusion. The results of a single-arm, multi-center, prospective clinical study enrolling 64 AA patients with transfusion-related iron overload confirmed the effectiveness and safety of deferasirox in reducing patients' ferritin levels. A prospective, observational study in my country using liver, pancreas, and heart as monitoring indicators confirmed that deferasirox can improve organ function in patients with iron overload. The TELESTO study results released at ASH2018 also proved that deferasirox continuously reduces serum ferritin levels, while reducing the risk of heart function damage, liver function damage, transformation to leukemia and other events by 36.4%.

It is recommended that patients with iron accumulation, such as those who require long-term blood transfusion (blood transfusion volume up to 100 ml/kg) and whose serum ferritin exceeds 1000 μg/L, are initially recommended to take deferasirox at a dose of 20 mg/kg daily depending on their body weight. Depending on the improvement of serum ferritin indicators, patients may need to adjust or increase the dose of deferasirox. Generally, the dose will be increased in units of 5 mg/kg or 10 mg/kg, but the total dose should not exceed 30 mg/kg per day.

The above is the effect of treating iron accumulation, I hope it can help you!