依普利酮能长期服用吗？

Eplerenone (Planep) is a selective aldosterone receptor antagonist with a similar structure to aldosterone. It can block the sodium-preserving potassium excretion and water retention effects of aldosterone, thus acting as a potassium-preserving diuretic. Eplerenone is effective in reducing systolic blood pressure in patients with resistant hypertension. The European Hypertension Guidelines recommend aldosterone receptor antagonists as a treatment for resistant hypertension, and the Japanese Hypertension Guidelines also recommend them as the fourth drug in combination therapy.

Eplerenone can be used in combination with angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers, calcium antagonists, alpha-blockers, and hydrochlorothiazide. The antihypertensive effect of eplerenone (Planep) can appear within 2 weeks of taking the drug. The clinical advantages of eplerenone: 1. For the treatment of heart failure after acute myocardial infarction, combined with standard treatment drugs can reduce the total mortality rate in the treatment group by 15% (P=0.008); 2. Eplerenone is as effective as enalapril in reversing left ventricular hypertrophy and hypertension, with fewer cough side effects, and the combined application effect is more obvious; 3. Few adverse reactions, except for the adverse reaction of elevated blood potassium, other adverse reactions are no different from the placebo group; 4. There are almost no sex hormone-related side effects of spironolactone.

Can eplerenone be taken long-term?

The new generation of selective aldosterone antagonist eplerenone (Planep) was developed by Pfizer/Pharmacia under the trade name Inspra. It was first launched in the United States in 2002 and is used for the treatment of hypertension, heart failure and myocardial infarction. It has definite efficacy in treating hypertension, heart failure and myocardial infarction, has fewer adverse reactions and is well tolerated. Eplerenone can be used until drug resistance develops. Eplerenone requires a certain period of time to achieve the best effect of lowering blood pressure. It is also very safe when used in combination with other antihypertensive drugs. Therefore, it is recommended that when taking eplerenone early, it can be combined with other antihypertensive drugs to control blood pressure. After eplerenone reaches the peak effect, it can be used alone.