依普利酮治疗高血压效果好吗？

Eplerenone is a new type of selective aldosterone receptor blocker that can effectively control hypertension, reduce damage to target organs such as the heart, brain and kidneys, and improve microalbuminuria in patients with type 2 diabetes.

Is eplerenone effective in treating high blood pressure?

Clinical trials evaluate the clinical efficacy and safety of eplerenone in the treatment of mild to moderate essential hypertension. Methods: 72 patients with mild to moderate hypertension were randomly divided into: ambulatory blood pressure group, losartan group, and eplerenone group, with 24 cases in each group. The losartan group and the eplerenone group adopted a double-simulation and positive drug parallel control method and received losartan and eplerenone treatment respectively. After 4 weeks of treatment, if the blood pressure did not reach the target, the drug dose was doubled and the treatment continued for 4 weeks; if the blood pressure reached the target, the original dose was maintained and the treatment continued for 4 weeks. The ambulatory blood pressure group took eplerenone 25 mg once a day.

The results showed that after 8 weeks of treatment, compared with before treatment, the average sitting diastolic blood pressure of the eplerenone group decreased by (13.32±4.57) mmHg, and that of the losartan group decreased by (10.90±5.64) mmHg. There was no statistically significant difference between the two groups. After 8 weeks of treatment, compared with before treatment, the average sitting systolic blood pressure of the eplerenone group decreased by (23.56±9.39) mmHg, and that of the losartan group decreased by (18.67±7.00) mmHg. The difference between the two groups was not statistically significant; the average sitting systolic blood pressure of the eplerenone group and the losartan group The sitting blood pressure compliance rates were 83.33% and 91.30% respectively, with no statistically significant difference between the two groups; the effective rates of blood pressure reduction were 75.0% and 60.9%, respectively, and the total effective rates of blood pressure reduction were 91.7% and 91.3%, respectively. There was no statistical significance in the differences between the groups in the effective rate of blood pressure reduction and the total effective rate of blood pressure reduction.