依普利酮（Inspra）使用说明

The indications of eplerenone (Inspra) are: 1. Congestive heart failure after acute myocardial infarction: Eplerenone (Inspra) can improve the quality of life of patients with left ventricular dysfunction (ejection fraction ≤ 40%). Clinical trials have proven that this product can also be used for heart failure after acute myocardial infarction. 2. Anti-hypertension: Eplerenone (Inspra) can be used alone or in combination with other antihypertensive drugs for the treatment of hypertension.

Eplerenone (Inspra) usage and dosage: 1. Congestive heart failure after acute myocardial infarction: The recommended dose is 50 mg/time, once/day. The initial dose should be 25 mg/time, once/day, and within 4 weeks, the dose should be gradually increased to 50 mg/time, once/day if the patient tolerates it. 2. Anti-hypertensive: Eplerenone can be used alone or in combination with other anti-hypertensive drugs. The recommended initial dose for use alone is 50mg/time, once/day. Obvious pressure-reducing effect will appear within four weeks of taking the medicine. If the pressure effect is not obvious, it can be increased to 50mg/time, 2 times/day. Higher dosages are not recommended, otherwise there is an increased risk of adverse reactions such as hyperkalemia.

Precautions for patients using eplerenone (Inspra): (1) Eplerenone cannot be combined with potassium supplements, potassium-containing salts, or contraindicated drugs (potassium-sparing diuretics, strong inhibitors of CYP450 liver enzymes). (2) Non-steroidal anti-inflammatory drugs and lithium can affect the blood concentration of this product and affect its efficacy. (3) Patients with high serum potassium, type 2 diabetes patients with microalbuminuria, patients with high serum creatinine levels, and patients with muscle intoxication clearance <50 mL/min should not take eplerenone. (4) Pregnant women, children, and those with hepatic or renal insufficiency should use eplerenone (Inspra) with caution.