利伐沙班副作用有哪些？

It is an oral, bioavailable factor Xa inhibitor that selectively blocks the active site of factor Xa and does not require cofactors (such as antithrombin III) to exert activity. Factor X is activated into factor Xa (FXa) through endogenous and exogenous pathways, which plays an important role in the coagulation cascade. Rivaroxaban inhibits the activity of Factor Anti-factor Xa activity is also affected by rivaroxaban.

Rivaroxaban is a highly selective, oral drug that directly inhibits factor Xa. Compared with warfarin, its effect is safe, effective and lasts for a long time, and does not require monitoring of coagulation. By inhibiting factor Rivaroxaban does not inhibit thrombin (activated factor II) and has no proven effect on platelets. A dose-dependent inhibition of factor Xa activity by rivaroxaban has been observed in humans. The effect of rivaroxaban on prothrombin time (PT) has a dose-effect relationship. If NeopLastin is used for content measurement, it is closely related to the plasma concentration (correlation coefficient is 0.98). Different results may occur with other reagents. Reading the PT should be completed within seconds because the International Normalized Ratio (INR) is calibrated and validated only for coumarins and not for other anticoagulants.

  As we all know, taking any drug has side effects, so what are the possible side effects of taking Varoxaban?

First of all, the most common side effect of rivaroxaban tablets is bleeding. All anticoagulant drugs have a risk of bleeding, but the probability of clinical major bleeding is relatively low. Secondly, some patients may also experience skin reactions, and some patients may use rivaroxaban tablets, which may affect liver and kidney function to a certain extent, leading to an increase in creatinine and transaminases. In addition, relatively rare side effects such as vascular abnormalities, abnormal platelet counts, and changes in coagulation function may occur. Rivaroxaban tablets are a new type of oral anticoagulant, which is widely used in clinical practice due to its advantages. But after all, it is an anticoagulant with certain side effects. For pregnant women, whether it is to prevent or treat thrombosis, it will cause fetal malformations through the placenta. Anticoagulant treatment with rivaroxaban tablets for pregnant women and fetuses may also cause fetal bleeding. Therefore, women should not use rivaroxaban during pregnancy.

The above are the side effects, I hope they can help you.