How long should be the interval between repeated doses of Puleke, and what are the side effects?

In vivo studies have shown that Preclosumab is effective in both liver and kidney transplants and can be used to prevent graft rejection after liver or kidney transplantation. Plexif, also called tacrolimus capsules, works by combining it with cellular proteins to accumulate in cells and play a role. The combined complex inhibits the calcium ion-dependent information transduction pathway produced by T cells. So, how long is the interval between repeated doses of Plexif, and what are the side effects?

Usage and dosage

The re-dosing interval of Puraco is the time for adults to receive oral treatment after surgery. Patients with liver transplantation should start taking the drug within 6 hours after surgery, and patients with kidney transplantation should start taking the drug within 24 hours after surgery. For rejection reactions that are ineffective in traditional immunosuppressive treatment, patients should be switched from cyclosporine to Preclosumab, and the interval between the first doses of Preclosumab should not exceed 24 hours.

It is best to take the capsules of Precofur on an empty stomach or at least 1 hour before or 2-3 hours after eating to achieve maximum absorption. Initial immunosuppressive dose - Adults: 0.1-0.2 mg/kg/day for adult liver transplant patients and 0.15-0.3 mg/kg/day for kidney transplant patients, taken orally in 2 divided doses. When oral capsules are taken, they usually need to be taken continuously to inhibit transplant rejection, and there is no limit on the treatment period.

Precofur side effects

Proclofor is a highly immunosuppressive drug, and its activity has been confirmed in in vitro and in vivo experiments. However, this product also has side effects, such as high blood pressure, abnormal kidney function (such as increased blood creatinine, increase or decrease in urea nitrogen and urine output), tremor, headache, insomnia, disturbance of consciousness, visual disorders (such as cataracts, amblyopia), constipation, diarrhea, nausea, constipation, diarrhea, nausea, etc. In addition, autoimmune diseases, allergic reactions, infections, etc. are also side effects of this product. It is recommended that patients follow the doctor's instructions and treat symptoms. For more details, patients can consult the medical companion and passenger service personnel.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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