What are the efficacy and functions of Precofu, and are there any serious side effects?

Precofu can treat graft rejection that cannot be controlled by other immunosuppressive drugs after liver and kidney transplantation, and can prevent graft rejection after liver and kidney transplantation. It is a highly immunosuppressive drug. Also called tacrolimus capsules, it is developed and produced by Astellas Pharmaceutical Co., Ltd. of Japan. Today, let’s learn more about the efficacy and role of Procrolimus. Are there any serious side effects?

Efficacy

The function of Precofur is to combine with cellular proteins to accumulate and exert its effects in cells. The combined complex inhibits the calcium ion-dependent information transduction pathway produced by T cells, thereby preventing the transcription of discontinuous lymphokine genes. Precofur inhibits the production of cytotoxic lymphocytes, which are the main cause of transplant rejection, inhibits the activation of T cells and the proliferation of T helper cell-dependent B cells, thereby exerting its efficacy.

The first dose of immunosuppression: 0.1-0.2 mg/kg/day for adult liver transplant patients and 0.15-0.3 mg/kg/day for kidney transplant patients, taken orally in 2 divided doses. Dosing should be started approximately 6 hours after liver transplant surgery and within 24 hours after kidney transplant surgery. It is recommended that patients follow the doctor's instructions and do not change the dosage and usage at will.

Are there any serious side effects of Precofur?

Any drug will have certain side effects, and Procrof also has side effects, and there are many side effects. Common side effects of Procrof include high blood pressure, tremor, headache, insomnia, disturbance of consciousness, visual disorders (such as cataracts, amblyopia), abnormal kidney function (such as increased blood creatinine, increase or decrease in urea nitrogen and urine output), constipation, diarrhea, nausea, hypercalcemia, hyperglycemia, hypophosphatemia, leukocyte hyperplasia, etc.

In addition, the occasional side effects of Proclore include angina pectoris, palpitations, effusion (such as pericardial effusion, pleural effusion), depression, neuropathy, neurosis, anxiety, nervousness, emotional instability, amnesia, encephalopathy, renal tissue damage (such as renal tubular necrosis), cholangitis, vomiting, Abnormal liver function, jaundice, changes in weight and appetite, inflammatory symptoms, gastrointestinal disorders, diabetes, acid/alkaline imbalance, hyperemia, hypokalemia, hyperuricemia (including gout), increased amylase, etc. The side effects are different depending on the body constitution and disease. For more details, please consult the medical companion passenger service staff.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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