他克莫司多少钱一盒?在哪里购买?

Tacrolimus is an important immunosuppressant and is widely used in anti-rejection treatment after organ transplantation. This article will explore the price, availability of tacrolimus, and its pharmacokinetic properties, aiming to provide patients with detailed information.

How much does a box of tacrolimus cost?

Price of Japan's Towa Pharmaceutical version

The specifications of tacrolimus capsules produced by Japan's Towa Pharmaceutical are 0.5mg*100 tablets/box, and the price is about US$110. This price reflects the high quality and R&D cost of the original drug.

Price of generic drugs

There are also a variety of generic drugs of tacrolimus available on the market. These generic drugs are usually cheaper than the original drugs. The specific prices vary depending on the manufacturer and regional policies. In the Chinese market, due to the participation of multiple companies, the price of generic drugs may be more competitive.

Medical insurance reimbursement situation

Tacrolimus has been included in the reimbursement scope of China’s medical insurance, which means that eligible patients can enjoy a certain percentage of cost reductions, further reducing the financial burden on patients.

Where to buy tacrolimus

Hospital pharmacy

In most cases, patients can purchase tacrolimus directly at the hospital pharmacy where they receive treatment. This method is not only convenient and fast, but also ensures the authenticity and quality of medicines.

Regular pharmacies

Some large chain pharmacies or qualified professional pharmacies may also provide tacrolimus sales services. When purchasing, be sure to confirm the legality of the pharmacy and the authenticity of the drug.

Online platform

With the development of the Internet, some formal pharmaceutical e-commerce platforms have also begun to provide tacrolimus sales services. When choosing such a platform, you should carefully verify its legality and credibility to avoid purchasing fake medicines.

Tacrolimus pharmacokinetics

Absorption characteristics

Tacrolimus has the best bioavailability when taken on an empty stomach. High-fat diet will reduce its absorption rate and extent. Time to peak (Tmax) is approximately 2 hours and is observed in healthy subjects.

Distribution characteristics

The plasma protein binding rate of this drug is as high as about 99%, and it mainly binds to albumin and α-1 acidic glycoprotein. This indicates that the distribution of tacrolimus in the body is highly selective.

Metabolism and excretion

The CYP3A4/5 enzyme system dominates the metabolism of tacrolimus and generates 8 metabolites, of which 31-desmethyltacrolimus is active. The half-life is about 38 hours, most of it is excreted through feces, and a small amount passes through urine.