磷酸二甲酯片(Astomin)的注意事项和药物相互作用

Dimethyl phosphate tablets (Astomin) may cause some side effects during medication. It is recommended to consult a doctor to understand the specific side effects.

Precautions for Dimethyl Phosphate Tablets (Astomin)

1. Important dosing warnings

Packed in aluminum foil (PTPsheet), the tablets must be taken out of the aluminum foil before taking. It is strictly forbidden to swallow the entire tablet directly.

The hard and sharp corners of aluminum foil may puncture the esophageal mucosa, leading to serious life-threatening complications such as perforation and mediastinitis.

2. Medication contraindications and warnings for special groups

(1) Pregnant women: The principle is "use with caution". Use can only be considered when the doctor clearly determines that the benefits of treatment to the mother far outweigh the potential risks to the fetus.

(2) Lactating women: During the medication period, the necessity of treatment must be weighed against the benefits of breastfeeding, and the doctor and patient will decide whether to suspend breastfeeding through joint discussion.

(3) Elderly patients: The physiological functions (especially liver and kidney functions) of elderly patients generally decrease, which may lead to slower drug metabolism and increased blood drug concentration. Therefore, the drug needs to be used with caution, the initial dose should be reduced, and the response should be closely observed.

(4) Diabetic patients: This product may cause mild changes in glucose tolerance. Diabetic patients need to strengthen blood sugar monitoring during medication to prevent blood sugar fluctuations.

3. Driving and operating machinery warning

Since dimethyl phosphate tablets may cause dizziness, drowsiness and other nervous system side effects, you should avoid engaging in activities that require high concentration such as driving, operating precision machinery or working at heights after taking the drug.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Drug interactions with Dimethyl Phosphate Tablets (Astomin)

1. Interactions that require vigilance

Although the specific interacting drugs are not clearly listed in the instructions, based on its pharmacological effects (suppressing the cough center) and theoretical analysis, extreme caution is required when combining this product with the following drugs, as it may enhance the inhibitory effect on the central nervous system.

Including sedative-hypnotics (such as diazepam, estazolam, etc.), anti-anxiety drugs, and some anti-allergic drugs (such as chlorpheniramine and other first-generation antihistamines).

2. Principles in the absence of clear information

For other drugs not mentioned in the instructions, the safest principle is to inform the doctor of all the drugs you are taking (including prescription drugs, over-the-counter drugs and health care products) when you see a doctor, and let the doctor make a comprehensive judgment.

Adverse reactions of dimethyl phosphate tablets (Astomin)

According to clinical trial data, side effects can be summarized as follows according to frequency of occurrence:

1. Relatively common (incidence rate 1%-5%)

(1), Psychological nervous system: dizziness, drowsiness, headache/heavy head. This is the most common category of side effects.

(2) Digestive system: dry mouth, loss of appetite, nausea, vomiting, diarrhea.

2. Rare (incidence less than 0.1%)

(1) Psychological and nervous system: feeling of powerlessness and fatigue.

(2) Cardiovascular system: frequent pulse (fast heartbeat), palpitations (heart palpitations), facial flushing.

(3), allergic reaction: rash. Although the frequency is unknown, please be vigilant.

Coping strategies for adverse reactions of dimethyl phosphate tablets (Astomin)

1. Mild side effects: such as slight dry mouth and dizziness. Symptomatic measures can be taken, such as drinking more water if the mouth is dry and sitting quietly to rest when feeling dizzy. Symptoms usually lessen as the body adapts.

2. Side effects that require discontinuation of the drug and medical treatment: allergic symptoms such as rash and itching; severe or persistent heart palpitations and dizziness; severe digestive system reactions that affect normal eating. Any other serious discomfort that is disturbing to the patient.

Once the above symptoms that require vigilance appear, you should stop taking the medicine immediately and seek medical consultation in time.