2025年磷酸二甲酯片(Astomin)最新价格是多少钱一盒？

Since its launch in Japan in 1974, dimethyl phosphate tablets (Astomin) have attracted attention due to their good efficacy and safety.

2025 Dimethyl Phosphate Tablets (Astomin) Price Reference

The price is affected by various factors such as region, purchasing channel, exchange rate changes, etc., so it is impossible to provide an accurate price.

As a generic prescription drug mainly sold in the Japanese market, its price is relatively stable. Specific to individual purchases, the price will vary greatly depending on different pharmacies, whether it is included in the local medical insurance directory, and the reimbursement ratio.

If you want to get the most accurate price in 2025, you can consult local hospital pharmacies or regular pharmacies, or you can check the national or regional drug centralized procurement platform. If the drug has been listed in some areas and has been included in the centralized procurement, the platform will announce the winning price.

The pictures are from public channels (such as the official website of the FDA, the official website of the original drug manufacturer, etc.) and are for reference only.

Main factors affecting the price of dimethyl phosphate tablets (Astomin)

1. Market and policy factors

The operating costs and profit margins of different distributors and pharmacies will lead to differences in terminal selling prices.

If dimethyl phosphate tablets are included in the local basic medical insurance directory, the medical insurance fund will bear a certain proportion of the cost, and the patient's out-of-pocket portion will be significantly reduced. On the contrary, if you pay all yourself, the burden will be heavier.

If there are generic drugs (dimethyl phosphate) with the same ingredients produced by other pharmaceutical companies on the market, competition will usually drive down the price. If it is still an exclusive or main product, the price will be relatively strong.

2. Product factors

Drugs usually have different packaging specifications (such as 100 tablets/box, 1000 tablets/bottle). The greater the number of pills in a single box, the higher the total price is usually, but it may be more economical to convert it into a single pill price.

Dimethyl phosphate tablets (Astomin) pharmacokinetics

1. Absorption and peak time

(1) Rapid absorption: After a single oral administration in healthy adults, dimethyl phosphate can be rapidly absorbed by the gastrointestinal tract.

(2) Peak time: Within 1 to 2 hours after taking the medicine, the drug concentration in the blood can reach the peak (C~max~), which means that the drug can exert its antitussive effect relatively quickly.

2. Metabolism and activity

Dimethyl phosphate tablets will be metabolized by the liver and other organs in the body. Studies have shown that its metabolites have almost no antitussive effect.

3. Excretion pathways and rates

(1) Mainly excreted through urine: dimethyl phosphate is mainly excreted in the form of urine through the kidneys.

(2) Excretion rate: Within 24 hours, about 60% of the administered dose will be excreted in the urine. This indicates that the clearance rate of the drug is moderate, supporting a three-times-daily dosing regimen to maintain stable plasma concentrations.

(3) Few prototype drugs: The proportion of prototype drugs (unmetabolized) detected in urine is very low (less than 2%), and most of them have been converted into metabolites, confirming their high degree of metabolism.