Where can I buy Sotoraxibu in the country?

The Lucius version of Sotorasib (AMG510) has not been launched in mainland China as of March 27, 2024. The purchasing methods currently known include:

1. Hospital pharmacy:

The most direct way to purchase Sotorasib is in the hospital pharmacy. Since this drug is a prescription drug, you will need a doctor's prescription before you can buy it at the hospital pharmacy. Please note that hospital pharmacy prices may be higher than other channels.

2. Overseas medical service institutions:

In addition to hospital pharmacies, you can also contact overseas pharmacies at some well-known overseas medical service institutions to purchase Sotoracib. These overseas medical service agencies usually provide a convenient and fast shopping experience, and the prices are relatively low. However, be sure to choose a regular and reputable online pharmacy to make sure your rights and interests are protected.

3. Domestic pharmacies or medical institutions:

According to the search results, sotoraxibu may be available in some pharmacies or medical institutions, and patients can consult and purchase it at domestic pharmacies and hospitals. The price of AMG510 will vary from place to place. Patients are advised to consult their doctor for specific prices.

4. Online drug sales platforms:

Some legal online drug sales platforms may provide sales services for Sotorasibu. When using these platforms, patients should ensure the legality of the platform and the authenticity of the medicines, and follow the doctor's prescriptions and instructions.

No matter which purchasing channel you choose, you should pay attention to the quality and safety of drugs, and abide by relevant laws and regulations to avoid illegal activities. Due to the high price of sotorasibu, patients and family members should consider the financial burden of the drug and use it rationally under the guidance of doctors. If you have any questions about the purchasing channel or the authenticity of the medicine, it is recommended to seek help from a professional medical institution.

When purchasing Sotorasib, you need to pay attention to the following points:

1. Doctor’s prescription:

Sotorasib is a prescription drug, so you need a doctor’s prescription to purchase it. Before use, your doctor should evaluate your condition and genetic mutation to confirm whether the patient is suitable for use .

2. Drug indications:

Sotorasiib is suitable for the treatment of adult patients with KRAS G12C mutation, locally advanced or metastatic non-small cell lung cancer (NSCLC) who have received at least one systemic therapy. Make sure your condition matches the medicine's indications.

3. Purchase channels:

Choose legal and formal channels to purchase, such as hospital pharmacies or certified online pharmacies. Avoid purchasing through illegal channels to ensure the authenticity and quality of medicines.

Efficacy of sotorasiib

A randomized, open-label, phase 3 trial enrolling patients aged at least 18 years with KRAS G12C-mutated advanced NSCLC who had progressed after prior platinum-based chemotherapy and a PD-1 or PD-L1 inhibitor.

345 patients were randomly assigned to receive sotoraxib (n=171 [50%]) or docetaxel (n=174 [50%]). 169 (99%) patients in the sotoraxib group and 151 (87%) in the docetaxel group received at least one dose of treatment.

Trial results

After a median follow-up of 17·7 months, the study met its primary endpoint of a statistically significant increase in progression-free survival (median progression-free survival) of 5·6 months with sotolacil compared with docetaxel.

Drug safety

Compared with docetaxel, sotoraxib was well tolerated, with fewer adverse events of grade 3 or worse (n=56 [33%] vs n=61 [40%]) and serious treatment-related adverse events (n=18 [11%] vs n=34 [23%]).

For sotorasib, the most common grade 3 or worse treatment-related adverse events were diarrhea (n = 20 [12%]), increased alanine aminotransferase (n = 13 [8%]), and increased aspartate aminotransferase (n = 9 [5%]). For docetaxel, the most common grade 3 or worse treatment-related adverse events were neutropenia (n=13 [9%]), fatigue (n=9 [6%]), and febrile neutropenia (n=8 [5%]).

Conclusion

Compared with docetaxel, sotoraxib significantly prolonged progression-free survival and had a more favorable safety profile in patients with advanced NSCLC who had KRAS G12C mutations and who had been previously treated with other anticancer drugs.

For more information on the efficacy of sotoracib, please click: This article has a detailed introduction.

Sotorasiib drug interactions

1. Patients are advised to inform their doctors of all concomitant medications, including prescription drugs, over-the-counter drugs, vitamins, dietary and herbal products.

2. Inform patients to avoid using proton pump inhibitors and H 2 receptor antagonists when taking sotoraxib.

3. If coadministration with acid reducing agents cannot be avoided, inform patients to take sotoraxib 4 hours before or 10 hours after the topical antacid.

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