Guide to dietary taboos while taking crizotinib

Introduction: Crizotinib is a drug used to treat specific types of non-small cell lung cancer. During treatment, patients should pay attention to their diet, such as avoiding spicy food, smoking and drinking, grapefruit and its products, etc. Otherwise, it may affect drug absorption and even affect the blood concentration of the drug in the patient's body, thereby increasing the risk of side effects.

Spicy and irritating foods

Because itself can cause some nausea, stomach pain and other gastric discomforts in patients. If you eat spicy and irritating foods such as pepper, pepper, mustard, onion and ginger, Malatang, spicy hot pot at this time, it may aggravate the gastrointestinal adverse reactions such as nausea and vomiting caused by crizotinib.

Smoking and alcohol consumption

Tobacco and alcohol intake may affect liver function, thereby affecting the metabolism and clearance of crizotinib. In addition, alcohol may have adverse reactions with drugs. If you drink too much, it may be difficult to distinguish between a drunken state and an adverse drug reaction.

Grapefruit and its products

Crizotinib is metabolized by the CYP3A4 enzyme, and the furanocoumarins contained in grapefruit and grapefruit juice can inhibit the activity of the CYP3A4 enzyme, which may lead to an increase in the blood concentration of crizotinib and increase the risk of side effects. Therefore, grapefruit, grapefruit juice, and foods and beverages containing grapefruit ingredients should be avoided.

High-fat diet

Concurrent intake of crizotinib and high-fat food may affect the absorption of the drug. Therefore, you should try to avoid eating large amounts of fat, fried food, butter and other high-fat foods in a short period of time before and after taking the medicine.

Foods rich in vitamin K

Since crizotinib may increase the risk of bleeding, if patients consume a large amount of foods rich in vitamin K, such as green leafy vegetables, soy products, cheese, etc., the effect of anticoagulant drugs may be affected. If patients are also taking anticoagulants, vitamin K intake should be kept relatively stable.

During crizotinib treatment, in order to reduce the burden on the gastrointestinal tract, it is recommended that patients adopt a diet of small meals and frequent meals to avoid eating too much at one time. At the same time, you should pay attention to drinking an appropriate amount of water. Drinking an appropriate amount of water can help maintain the body's water balance. Especially when adverse reactions such as diarrhea occur, additional water and electrolytes need to be supplemented.