How many tablets of Deflazacort are in a box and how long can it be taken?

How many tablets of deflazacort per box?

It is indicated for the treatment of Duchenne muscular dystrophy (DMD) in adults and children at least 2 years of age to improve muscle strength, improve timed motor function, improve lung function, delay loss of walking, reduce the need for scoliosis surgery, delay the onset of cardiomyopathy, and improve survival. The specification of deflazacort is a box of 6mg*100 tablets. It is understood that the price of the German direct mail version of deflazacort, 6mg*100 tablets, is about $850 per box. However, overseas drug prices are not fixed due to exchange rate fluctuations.

How long can I take deflazacort?

The once-daily dose is approximately 0.9 mg/kg/day orally, which is based on the patient's weight. Clinical trials have shown that deflazacort has significant efficacy and can prolong the survival period of patients and reduce their pain. Patients treated with deflazacort should strictly follow the doctor's diagnosis and treatment recommendations. The specific duration of use should be determined based on the patient's condition.

A clinical study including 196 DMD patients aged 5 to 15 years showed the effectiveness of deflazacort. The trial results showed that at 12 weeks, compared with the placebo group, the muscle strength of patients in the deflazacort treatment group improved and was maintained until 52 weeks.

A separate trial involving 29 men and lasting 104 weeks showed that deflazacort was significantly better than placebo on measures of mean muscle strength. Additionally, patients taking deflazacort also appeared to lose the ability to walk later than those taking placebo.

Deflazacort is a corticosteroid prodrug, and its active metabolite 21-desDFZ acts through the glucocorticoid receptor to exert anti-inflammatory and immunosuppressive effects. The exact mechanism by which deflazacort exerts its therapeutic effects in patients with DMD is unknown. It is recommended that patients take medication under the guidance of a doctor and receive symptomatic treatment.

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