氨己烯酸片(喜保宁)吃多长时间有效果

(Vigabatrin) is a structural analog of gamma-aminobutyric acid (GABA). It inhibits the catabolism of GABA by irreversibly inhibiting GABA transaminase, thereby increasing the concentration of GABA in the brain and achieving anti-epileptic therapeutic effects. Vigabatrin was actually approved for marketing in the UK as early as 1989. It was not until 2009 that the US Food and Drug Administration (FDA) approved it for the treatment of infantile spasms and refractory focal epilepsy, making it one of the first-choice drugs for the treatment of infantile spasms, especially for patients with tuberous sclerosis.

We have collected the following test data: Using the drug-increasing test method, we explored the therapeutic value of vigabatrin (vigabatrin) for refractory epilepsy in children.

In the trial, 25 children were treated with vigabatrin to observe the efficacy and safety of the drug. The results showed that 2 months after taking the medicine, the total effective rate was 68.0%. A total of 24 cases took the medicine for ≥4 months, and the total effective rate was 70.8% (21/24). After taking vigabatrin, phenobarbital blood concentrations are lower than before taking the drug. The serum alanine aminotransferase level was lower than before taking the drug.

In terms of safety, 22 of the children who received treatment had no side effects; 2 cases developed symptoms of mild dizziness and drowsiness early after taking the drug, but these symptoms could be relieved by themselves; 1 case developed severe restlessness and terminated treatment. From experiments, we can see that vigabatrin has a good effect on children with refractory epilepsy, and children have good tolerance to it.

How long does it take to take vigabatrin tablets (Vigabatrin) to be effective?

In foreign literature, the therapeutic dose of (Vigabatrin) is 0.10 to 0.15g/(kg·d), which usually takes effect 2 weeks after the initial treatment, manifested by the reduction or disappearance of convulsive attacks and the disappearance of peak arrhythmia-like EEG. Patients need to follow the doctor's instructions carefully while taking the medication and do relevant examinations.

Recommended related hot articles: /newsDetail/84428.html