氨己烯酸片(喜保宁)的效果好吗

Is (Vigabatrin) effective against epilepsy?

Due to different starting sites and transmission methods of abnormal discharges, the clinical manifestations of epileptic seizures are complex and diverse, and can manifest as paroxysmal motor, sensory, autonomic nervous system, consciousness and mental disorders. There are many causes of epilepsy. After regular anti-epileptic drug treatment, about 70% of patients with epilepsy can have their seizures under control, and 50% to 60% of them can be cured after 2 to 5 years of treatment, and the patients can work and live like normal people.

Ion channels are the basis for regulating the excitability of excitable tissues in the body, and mutations in their coding genes can affect ion channel functions, leading to the occurrence of certain genetic diseases. It is currently believed that many human idiopathic epilepsy are caused by ion channelopathies, that is, defective genes encoding defective ion channel proteins. Among them, the research on the correlation between sodium ion, potassium ion, and calcium ion channels and epilepsy is relatively clear.

Vigabatrin tablets (Vigabatrin) are the drug of choice for TSC epilepsy in foreign countries. In terms of controlling TSC epileptic seizures, about 95% of children have a good response to vigabatrin tablets. Once a seizure is found, regardless of form, vigabatrin tablets (Vigabatrin) can be the first choice, and the effect is better when used for the first time. Especially for infantile spasms (peak arrhythmia on electroencephalogram), vigabatrin tablets should be taken as soon as possible.

Vigabatrin can cause permanent vision loss in infants, children, and adults, including progressive and permanent bilateral concentric visual field constriction in >30% of patients, ranging in severity from mild to severe, including tunnel vision to visual acuity fixed within 10 degrees, and can lead to disability.

Treatment with Vigabatrin may affect your ability to drive and use machinery. Generally, patients with uncontrolled epilepsy are not allowed to drive or operate potentially dangerous machinery. In view of reports of drowsiness in clinical use of Vigabatrin, patients should be warned before initiating treatment with this drug.

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