赛诺菲氨己烯酸效果怎么样？

It has anti-epileptic effects, and its mechanism of action is to irreversibly inhibit GABA aminotransferase (GABA-T) and increase the concentration of GABA in the brain to exert its effects. In 2009, the US FDA approved the use of vigabatrin for infantile spasms in the United States. Today we will learn more about the effectiveness of Sanofi vigabatrin?

Clinical trials explore the therapeutic effect of the rare disease drug vigabatrin tablets on refractory epilepsy in children. The drug-increasing test method was used to observe the efficacy and safety of the drug on 25 children. Two months after taking the medicine, the total effective rate was 68.0%. There were 24 patients who took the medicine for ≥4 months, and the total effective rate was 70.8% (21/24). After administration of vigabatrin, phenobarbital blood concentrations are lower than before administration.

The serum alanine aminotransferase level was lower than before taking the medicine. No side effects were seen in 32 cases. 2 cases developed mild dizziness and drowsiness in the early stage after taking the medicine, which were relieved by themselves; 1 case developed severe restlessness and terminated treatment. Observation results show that vigabatrin tablets are more effective in treating refractory epilepsy in children and have less adverse side effects.

Vigabatrin tablets may also be used in infants with West syndrome (infantile spasms), which is generally unresponsive to conventional antiepileptic drugs. As an auxiliary therapeutic drug, vigabatrin tablets can achieve better efficacy. When used alone, it is effective in the treatment of newly diagnosed patients.

Sanofi is a leading global pharmaceutical and health company that researches, develops and promotes innovative treatment solutions based on patient needs. Sanofi's main businesses cover three areas: pharmaceuticals, human vaccines and animal health. Sanofi has innovative products in the fields of cardiovascular diseases, diabetes, tumors, central nervous system diseases, internal medicine diseases and other fields, focusing on patient needs.

Vigabatrin tablets are absorbed rapidly after oral administration, and food does not affect its absorption rate. The peak plasma concentration is reached 2 hours after taking the drug, and t1/2 is 5-7 hours. When a single dose is 1-3g, the pharmacokinetics show a dose-linear relationship. If the patient has special circumstances, he or she needs to inform the doctor before starting treatment with vigabatrin tablets. The doctor will make adjustments to the patient's medication based on the actual situation to avoid harm to the patient due to incorrect medication.

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