呲仑帕奈注意事项和用药禁忌

It is the first highly selective, non-competitive AMPA glutamate receptor antagonist targeting the α-amino-3-hydroxy-5-methyl-4-isoranoxazole propionic acid (AMPA) receptor. It can selectively inhibit the increase in Ca2+ induced by AMPA and reduce the over-excitation of nerves. It is clinically used in combination with other anti-epileptic drugs to treat focal epilepsy.

Currently, parampanel is only approved in the United States for use as a single agent or as an add-on treatment for children with focal epilepsy over the age of 4. Some existing studies have shown that parampanel is a safe and effective anti-epileptic drug. However, there are relatively few data on the use of parampanel in Chinese children and adolescents.

For this reason, China's R&D department is also actively applying for extrapolation indications for phase III clinical trials to 4 to 12 years old and monotherapy. Starting from March 2020, we have observed the effectiveness and tolerability of parampanel as an add-on treatment for children with epilepsy over 4 years old. The results show that although most patients have a long history of epilepsy treatment and have used multiple anti-epileptic drugs in combination, none of them achieved satisfactory results. However, the frequency of seizures in children and adolescent patients who were added with parampanel was significantly reduced and they were well tolerated.

: Suicidal ideation, various neurological disorders, oral contraceptives, falls, attacks, other symptoms of mental illness, social environment, potential for abuse. The above are the precautions for parampanel. It is recommended that patients remember the above points during medication. Contraindications for the use of Parampanel: It is prohibited for those who are allergic to the active ingredients of this product or lactose. Because this product contains lactose, patients with the rare hereditary galactose intolerance, Lapp lactase deficiency, or glucose-galactose intractable disorder should not use this product.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.