呲仑帕奈应该怎么用？有什么副作用吗？

At present, about 30% of epilepsy cases are drug-refractory epilepsy. Children with drug-refractory epilepsy face many problems such as cognitive impairment, behavioral and mental health problems. As a new type of anti-epileptic seizure drug, it is a highly selective non-competitive AMPA receptor antagonist. It mainly inhibits the excessive neurotransmission induced by the excitatory transmitter glutamate through non-competitive binding with AMPA receptors on the postsynaptic membrane, limits the generation and spread of epileptic electrical activity, and thereby resists epileptic seizures. It is currently approved by the U.S. Food and Drug Administration for the monotherapy or add-on treatment of focal seizures (with or without secondary generalized seizures) in patients aged ≥4 years, and for the add-on treatment of generalized tonic-clonic seizures in patients aged ≥12 years. The China Food and Drug Administration approved the indication for the add-on treatment of focal seizures (with or without secondary generalized seizures) in adults and children ≥4 years of age.

How should Perampanel be used? Are there any side effects?

: Take once a day orally before going to bed, on an empty stomach or with food. This product should be swallowed whole and should not be chewed, crushed or broken. Since there are no marks on the medicine, this product cannot be opened evenly. Common side effects of this drug are falls, headache, irritability, nausea, drowsiness, fatigue, dizziness, etc.

Finally, the editor of Medical Companion Travel would like to remind patients who are currently using parampanel. Recently, there has been a lot of loose news saying that if the patient feels that the drug is not effective after using it, the drug dose can be increased, or that the drug dose can be reduced if the side effects are too great during the medication. These are not scientifically based. Only by carefully following the doctor's instructions can the drug itself be used to its greatest extent.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.