浅谈氨己烯酸片与婴儿痉挛症

Infantile spasms (IS) is an age-related epileptic encephalopathy that is most common in infancy. The age of onset is usually 3-12 months. It rarely occurs in infants over 2 years old. The reported incidence rate abroad is about 1/2000. The iconic clinical characteristics of this disease are a series of convulsive attacks, developmental retardation or regression, and a high degree of arrhythmia on the electroencephalogram. This disease was first reported and described by West in 1841, so we call the disease with the above three clinical characteristics West syndrome (WS). In the treatment of IS, the three internationally recognized first-line drugs are: ACTH, glucocorticoids and glucocorticoids.

A recently published foreign multi-center open-label randomized trial based on participation from many countries involved 377 patients. The results showed that compared with synthetic ACTH and glucocorticoids alone in the treatment of IS, vigabatrin tablets may be more effective in controlling spasticity in IS patients when combined with hormones.

: Average oral dose is 100 mg/kg daily (range 50-150 mg/kg). Common side effects of this drug are agitation, ataxia, fatigue, dizziness, confusion, memory loss, edema, hair loss, drowsiness, headache, nystagmus, nervousness, depression, occasional aggressive behavior, paresthesia, tremor, diplopia, weight gain, gastrointestinal disorders, etc. Finally, the editor of Medical Companion Travel would like to remind all patients who are currently using vigabatrin tablets that there have been a lot of rumors on the Internet and various platforms recently saying that increasing the dose of the drug can improve the therapeutic effect, or reducing the dose of the drug can reduce the occurrence of side effects. These are without any basis. Only by following the doctor's instructions can the effect of the drug itself be maximized.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.