氨己烯酸片(喜保宁)的副作用有哪些

(Vigabatrin) is a drug with anti-epileptic effects. Its mechanism of action is to irreversibly inhibit GABA aminotransferase (GABA-T) and increase the concentration of GABA in the brain. Clinical research results show that vigabatrin is an effective and safe anti-epileptic drug in the treatment of children with severe epilepsy, and is also effective in epilepsy patients with intellectual disabilities.

Let’s take a look at how to use vigabatrin in pediatric patients. The initial recommended dose for pediatric patients is 40mg/kg/day. Continued medication should be judged based on the patient's weight. The recommended dose for children weighing 10-15kg is 0.5-1g/day; the recommended dose for 15-30kg is 1-1.5g/day; the recommended dose for 30-50kg is 1.5-3g/day; the recommended dose for children over 50kg is 2-3g/day.

In recent years, vigabatrin has been used in children with TSC to effectively control epilepsy. Western countries even use vigabatrin tablets to prevent brain abnormalities in children with TSC who have not yet developed the disease. It can be seen that the effect is quite significant. However, it should be noted that the toxic effects of vigabatrin tablets on the retina may cause peripheral visual field defects in children, so regular ophthalmological monitoring is required.

Vigabatrin tablets (Vigabatrin) also have some common side effects that everyone needs to know about, including fatigue, drowsiness, dizziness, headache, confusion and depression. Occasional aggressive behavior and psychosis (more common in patients with a history of psychosis and behavioral problems), diplopia, memory loss, gastrointestinal disturbances, weight gain, edema, and hair loss. Neurosis, nystagmus, agitation, ataxia, paresthesia, and tremor may also occur.

Since each patient's physical condition is not exactly the same, the degree of side effects is not exactly the same. If serious side effects occur, please contact your doctor in time.

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