服用喜保宁(Sabril)的副作用和处理措施？

The side effects of taking Vigabatrin mainly include fatigue, drowsiness, headache, dizziness, etc. Targeted treatment measures can be carried out according to different side effects.

Vigabatrin

It is also vigabatrin tablets, the trade name is Sabril, and its English names are Vigabatrin, Sabrilex, and Vigadrone. Vigabatrin is a structural analog of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), which exerts its anti-epileptic effects by irreversibly inhibiting the degrading enzyme GABA-aminase, resulting in increased central nervous system (CNS) GABA levels.

Vigabatrin is one of the few anti-epileptic drugs (AEDs) that has a specific targeting mechanism and has subsequently been shown to work through this mechanism.

Side effects of taking Vigabatrin

For adult patients, most of the side effects of taking Vigabatrin are related to the central nervous system, such as sedation, headache, dizziness, drowsiness, fatigue and inability to concentrate. Common side effects in children include excitement or agitation. The frequency of this side effect is generally higher in the early stages of treatment and then gradually decreases over time.

Occasionally, side effects such as memory loss, diplopia, weight gain, gastrointestinal disorders, edema, and hair loss may occur when taking Vigabatrin. A serious side effect is permanent visual field constriction. In severe side effects, the ability to drive or operate potentially hazardous machinery may be affected.

Measures to deal with the side effects of Vigabatrin

1. Drowsiness and fatigue: Maintain a good work and rest routine, ensure adequate sleep, and increase rest time appropriately to avoid overexertion in a short period of time. At the same time, maintain good eating habits and increase nutrition to improve physical strength.

2. Headache and dizziness: Pay attention to rest, adjust your diet, maintain a low-salt diet, avoid standing or sitting for long periods of time, and increase appropriate exercise to improve blood circulation.

3. Weight gain: Control your diet and maintain moderate exercise to consume excess calories. You can also take some weight loss measures, such as low-calorie diet and aerobic exercise.

4. Gastrointestinal disorders: Avoid eating spicy, greasy, and irritating foods, such as peppers, fatty meats, etc., keep a light diet, and eat more vegetables and fruits. Increase exercise appropriately to improve gastrointestinal motility.

5. Edema: Adjust your diet, reduce salt intake, avoid standing or sitting for long periods of time, and increase appropriate aerobic exercise to help consume excess water.

6. Hair loss: Maintain a good work and rest routine and eating habits. During the period of using Vigabatrin, pay attention to hair care and avoid excessive perming and hair dyeing.

Contraindications of Vigabatrin

It is contraindicated for those who are allergic to Vigabatrin, as well as pregnant women and breast-feeding people.

Vigabatrin's

Vigabatrin (VGB) is a structural analog of gamma-aminobutyric acid (GABA), which irreversibly inhibits GABA-aminotransferase (GABA-T) and increases brain levels of GABA. VGB is being evaluated for the treatment of infantile spasms (IS) and refractory complex partial epilepsy (CPS). Spasms ceased after approximately 2 weeks of treatment, and rapid response has been achieved in patients with symptomatic tuberous sclerosis (TS) and other patients.

Summary

When taking Vigabatrin, you should strictly follow the correct medication method to avoid more side effects. If serious side effects occur, you should inform your doctor in time for treatment.

References:

Willmore LJ, Abelson MB, Ben-Menachem E, Pellock JM, Shields WD. Vigabatrin: 2008 update. Epilepsia. 2009 Feb;50(2):163-73. doi: 10.1111/j.1528-1167.2008.01988.x. PMID: 19230067.

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