氨己烯酸口服溶液用散的副作用和处理措施？

Vigabatrin oral solution powder is mainly used to treat infantile spasms, partial epilepsy and generalized epileptic seizures. The side effects of vigabatrin oral solution powder involve multiple systems. The side effects and side effects treatment measures will be explained in detail below.

About vigabatrin oral solution powder

It is granules, and its main ingredient is vigabatrin, a gamma-aminobutyric acid derivative, which can be used in combination with other drugs to treat refractory complex partial epilepsy and as a monotherapy for infantile spasms.

Side effects

1. Visual impairment: strabismus, conjunctivitis.

2. Gastrointestinal disorders: vomiting, constipation, diarrhea.

3. General diseases: fever.

4. Infectious diseases: upper respiratory tract infection, otitis media, viral infection, pneumonia, candida infection, ear infection, viral enteritis, urinary tract infection.

5. Metabolic and nutritional disorders: loss of appetite.

6. Nervous system diseases: sedation, drowsiness, convulsions, lethargy, hypotonia, and neonatal agitation.

7. Mental illness: irritability, insomnia.

8. Respiratory system diseases: cough.

9. Skin and subcutaneous tissue diseases: rash, pruritus.

Treatment measures

1. Conjunctivitis:

Keep eye hygiene, keep eyes clean, avoid excessive use of eyes, and avoid watching TV or computers for long periods of time.

2. Vomiting:

Maintain adequate fluid intake to prevent dehydration and avoid eating greasy food. If vomiting is severe, you may need to stop taking Vigabatrin Oral Solution Powder.

3. Constipation:

Increase dietary fiber intake, such as fresh fruits and vegetables, and use laxatives under the guidance of a doctor if necessary.

4. Diarrhea:

Maintain water and electrolyte balance, temporarily restrict diet if necessary, and seek medical attention if severe.

5. Fever:

Monitor body temperature. If the fever exceeds 38.5°C, you need to use antipyretics, such as acetaminophen and ibuprofen, as directed by your doctor, and drink more water and rest.

6. Upper respiratory tract infection:

Pay attention to rest, drink more water, and maintain indoor air circulation.

7. Loss of appetite:

Ensure nutrition, try to provide foods that the patient likes, try to eat small and frequent meals, and avoid eating greasy foods.

8. Sedation and drowsiness:

If symptoms are severe or persistent, it may be necessary to reduce or stop taking vigabatrin oral solution powder.

9. Convulsions and lethargy:

Stop taking vigabatrin oral solution and powder immediately and seek medical help.

10. Hypotonia:

Maintain adequate exercise and a balanced diet.

11. Neonatal restlessness, irritability, and insomnia:

If symptoms are severe or persistent, it may be necessary to reduce or stop taking vigabatrin oral solution powder.

12. Cough:

Drink more water and avoid inhaling irritants.

13. Rash and itching:

Keep the skin clean and dry and avoid excessive scratching. If symptoms are severe or persistent, you may need to seek advice from your doctor to stop taking Vigabatrin Oral Solution Powder.

Medication

1. Use of vigabatrin oral solution in powder may cause permanent bilateral concentric visual field constriction, including damage to the visual field due to narrowing of the visual field. In some cases, vigabatrin may also damage the central retina, causing vision loss.

2. Vision damage caused by vigabatrin is unpredictable and may occur within a few weeks of starting treatment or earlier, or at any time after starting treatment, or even months or years later.

3. Due to the risk of visual impairment, patients with infantile spasms who have no obvious clinical effect within 2-4 weeks of taking the medication should stop treatment, or who show obvious treatment failure earlier should stop treatment.

4. Unless the potential benefits of treatment outweigh the potential risks, patients with high risk or other types of irreversible visual impairment should not be treated with vigabatrin.

5. Unless the potential benefits of treatment outweigh the potential risks, vigabatrin should not be combined with drugs that can cause serious ophthalmic adverse reactions (such as retinopathy or glaucoma).

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