国内能够买到司替戊醇(Diacomit)吗？

It is available in China (Diacomit). Stiripentol is already on the market in China, but it has not been included in the medical insurance catalog as of January 2024. Therefore, patients can only purchase it in full at their own expense, or perhaps find overseas medical service agencies to help them purchase it. It is understood that the reference price of Diacomit (stiripentol oral suspension) in the specification of 250 mg*60 packets is about $3,300 per box, and the reference price in the specification of 500 mg*60 packets is about $6,000.

About stiripentol (Diacomit)

Stipentol is a new type of anti-epileptic drug developed by the French company Biocodcx. It has had good clinical response since its launch. Its mechanism of action is to inhibit cytochrome P450. The anti-epileptic effect of the drug is not obvious when used alone. When used in combination with sodium valproate and oxydiazepam, stiripentol has a good therapeutic effect on patients with severe myotic epilepsy. In addition, the drug can reduce the side effects of anti-epileptic drugs used in conjunction with it. Long-term use will have little impact on patients, making it an ideal drug for the treatment of epilepsy.

The role of stiripentol (Diacomit)

The mechanism by which stiripentol exerts its anticonvulsant effect in humans is unclear. Possible mechanisms of action include direct effects mediated through gamma-aminobutyric acid (GABA) A receptors and indirect effects involving inhibition of cytochrome P450 activity, resulting in increased blood levels of clobazam and its active metabolite. Stipentol increases GABAergic activity. At clinical doses, it can enhance central GABA neurotransmission by acting similarly to barbiturates in that it increases the duration of open GABA-A receptor channels in hippocampal slices. It has also been shown to increase GABA levels in brain tissue by interfering with its reuptake and metabolism.

How to purchase stiripentol (Diacomit) in China

On July 27, 2023, S4 Pharmaceutical Group announced that its generically developed stiripentol dry suspension (500mg and 250mg) was officially It was approved for marketing by the National Medical Products Administration (NMPA) and was deemed to have passed the consistency evaluation, making it the first domestic generic. Since then, patients can also purchase stiripentol (Diacomit) in China. However, the drug is not included in medical insurance and patients have to pay the full amount out of pocket.

However, overseas medical service institutions provide a convenient way to purchase medicines, allowing patients to enjoy more favorable and one-stop services. It is understood that the reference price of Diacomit (stiripentol oral suspension) for 250 mg*60 packs is about $3,300 per box, and the reference price for 500 mg*60 packs is about $6,000.

1. Purchase domestically by yourself

Stipentol is already on the market in China, and patients can go directly to pharmacies to purchase it. However, the following points need to be noted:

(1) High price: Since stiripentol has not yet been included in medical insurance, patients need to bear higher costs when purchasing it.

(2) Dependence on pharmacy inventory: The pharmacy may not be able to provide the required drugs due to insufficient inventory, requiring patients to make multiple trips or wait.

(3) Solve follow-up problems by yourself: After purchasing drugs by yourself, patients need to solve problems in drug storage and use by themselves. If they have questions or confusion about drugs, they may not be able to obtain timely professional guidance.

2. Purchase by overseas medical service institutions

Overseas medical service institutions provide a convenient and fast way to purchase drugs, which has the following advantages:

(1) Price advantage: patients can enjoy more economical prices when purchasing stiripentol through overseas medical service institutions. Due to differences in drug prices in different countries, you may save a lot of money by choosing the right country to purchase.

(2) Convenient drug purchase process: Overseas medical service institutions provide one-stop services, from drug consultation to delivery. Patients do not need to solve subsequent problems by themselves and enjoy a convenient drug purchase process.

(3) Supply guarantee: Overseas medical service institutions have established cooperative relationships with cooperative pharmacies or suppliers, which can ensure the provision of regular and reliable stiripentol.

3. The drug purchase process is as follows

(1) Consultation and formula preparation: Patients contact overseas medical service institutions to provide relevant medical information and prescriptions. The service will help prepare the documents and information needed to purchase the medication.

(2) Drug selection and ordering: Based on the patient's needs and prescriptions, the medical service institution assists in purchasing the appropriate stiripentol and orders it with the cooperative pharmacy or supplier.

(3) Payment and delivery: The patient receives a payment link and completes the payment through online payment. Medical service agencies assist in arranging the distribution and customs clearance of medicines.

(4) Drug collection: Patients receive drugs according to the agreed delivery method and time. All drugs are sent by overseas direct mail. After receiving them, patients should keep them properly to ensure the quality and integrity of the drugs.

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