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Vibatrin is an anti-epileptic drug used to treat epilepsy. Its main ingredient is vigabatrin. The drug is produced by French pharmaceutical companies such as Sanofi and is suitable for refractory complex partial seizures (CPS) and infantile spasms (IS). Vigabatrin works by inhibiting gamma-aminobutyric acid transaminase (GABA-T), thereby increasing levels of the inhibitory neurotransmitter GABA in the brain. Because of the risk of permanent vision loss, this drug must be used under strict supervision by a doctor.

Vigabatrin’s latest price list

The prices vary depending on the country of production and specifications. The following is the price information of several common versions currently on the market for patients' reference.

Drug Price

The Turkish version of French Sanofi Vigabatrin is 500mg*100 tablets, and the price is about US$155 per box. The Portuguese version is 500mg*60 capsules, and the price is about US$172 per box. The specifications of the Laos Lucius version are 500mg*100 tablets, and the price is about US$84 per box. Prices may vary due to exchange rate fluctuations or purchasing channels.

How to buy

The original Vigabatrin drug is not yet on the market in China, but the domestically produced Vigabatrin is already on the market. When purchasing, you need to provide a doctor's prescription and choose a regular pharmacy or authorized dealer.

It is recommended to consult a professional medical institution or pharmacist for medication guidance before purchasing.

Precautions when using Vigabatrin

When using Vigabatrin, you must strictly follow the doctor's instructions and pay attention to the following important matters to reduce the risk of medication.

Vision monitoring requirements

Vigabatrin may cause permanent vision loss, and regular eye examinations must be performed during medication. Adult patients should complete baseline examinations before taking the medication and within 4 weeks after taking the medication, and then re-examine every 3 months. For infants and young children who are unable to cooperate with the examination, doctors will evaluate the risk-benefit ratio and decide whether to continue taking the medication.

Dose for special groups

Patients with renal insufficiency need to adjust the dose: reduce the dose by 25% for mild injury, 50% for moderate injury, and 75% for severe injury. It is contraindicated for pregnant women and lactating women need to weigh the pros and cons. Elderly patients may need to reduce the dose because renal clearance is approximately 36% lower than that of younger patients.

If symptoms such as blurred vision and reduced peripheral vision occur during medication, you should seek medical attention immediately. Even after stopping the drug, visual acuity needs to continue to be monitored for 3-6 months.

How to take Vigabatrin

The usage and dosage of Vigabatrin need to be adjusted individually according to the patient's age, weight and indications. The following is a routine medication guide.

Usage

Vigabatrin tablets can be taken directly orally, with food or alone. For infants and young children, the powder preparation can be mixed with 10ml of water to form a 50mg/ml solution, and a special oral syringe can be used for accurate administration. The mixed solution should be taken immediately, and the remaining portion should be discarded and cannot be saved for reuse.

Recommended dose

The starting dose for the treatment of CPS in adults is 1000mg/day (divided into 2 times), which can be increased by 500mg every week, with a maximum dose of 3000mg/day. Children's dosage is based on body weight: 10-15kg, starting at 350mg/day and maintaining 1050mg/day. For patients with infantile spasms, the starting dose is 50 mg/kg/day and the maximum is 150 mg/kg/day.

Special attention should be paid: Vigabatrin needs to be discontinued gradually, and the dose should be reduced by 500mg per week for adults and one-third per week for children. Sudden discontinuation of the medication may cause seizures to worsen. Any medication adjustments should be made under the guidance of a physician.