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Phenobarnate is a new anti-epileptic drug mainly used to treat partial epileptic seizures. The drug is produced by the Italian company ANGELINI and is available in a variety of specifications. The price varies depending on the dosage and packaging. Understanding the dosage, cost structure, and medication precautions for special populations is of great significance to patient treatment planning. This article will elaborate on these three aspects to help patients plan a reasonable medication plan.

How many boxes of Phenobarate per treatment course

The dosage of the treatment course needs to be determined according to the patient's individual situation and the doctor's prescription. The drug adopts a progressive dosing schedule, and it usually takes several weeks to reach the maintenance dose.

Initial treatment stage

The initial stage of treatment usually starts with a low dose, and the 12.5mg+25mg*28 capsules are suitable for use at this stage. The initial treatment phase lasts 2-4 weeks for most patients and requires approximately 1-2 boxes of this specification.

Maintenance treatment stage

After reaching the maintenance dose, the 50mg or 200mg specifications are more economical and practical. Based on the standard maintenance dose of 50mg twice daily, the 50mg*84 capsules can be used for 6 weeks, and the 200mg*84 capsules can meet the needs for a longer period of time.

The specific amount of medication should be determined according to the individualized plan formulated by the doctor. Patients cannot adjust the medication plan on their own.

How much does a course of Phenobarate cost?

The price of Phenobarate is directly related to the specifications, and the combination of different dosages and packaging will affect the overall treatment cost.

Small size packaging price

The price of 12.5mg+25mg*28 tablets is about US$206, and the price of 50mg*14 tablets is about US$117. These specifications are suitable for use in the dose adjustment phase, but the long-term use cost is higher.

Large-size packaging price

The price of 50mg*84 capsules and 200mg*84 capsules are both about US$521. The unit price of large packaging is lower, suitable for use in the maintenance treatment stage, and can significantly reduce long-term medication costs.

Treatment cost estimate

Based on a standard 6-month treatment course, including 2 weeks of initial treatment and 5 and a half months of maintenance treatment, the total cost is approximately US$1,500-2,000, depending on the selected combination of specifications.

Drug prices may fluctuate depending on regions and purchasing channels. It is recommended to purchase through formal channels.

Usage of Phenomenate for Special Populations

Special groups need to pay special attention to dose adjustment and medication safety when using Phenomenate to avoid adverse reactions.

Patients with hepatic impairment

The maximum daily dose for patients with mild to moderate hepatic impairment (Child-Pugh class A/B) shall not exceed 200 mg. This drug is contraindicated in patients with severe hepatic impairment (Child-Pugh class C).

Patients with renal insufficiency

Patients with mild to moderate renal impairment (eGFR 30-90 mL/min) should use caution in reduced dosage. Phenobarate is contraindicated in patients with end-stage renal disease (eGFR <15 mL/min) or dialysis.

Elderly patients

Elderly patients may be more sensitive to drugs. It is recommended to start with a lower dose and slowly adjust to an effective dose. Adverse drug reactions need to be monitored closely.

Medications for special groups must be carried out under the strict supervision of doctors, and the therapeutic effect and safety must be regularly evaluated.