非奈利酮finerenone作用功效是什么？正确用法用量是什么

Finerenone is a first-in-class, nonsteroidal, selective mineralocorticoid receptor antagonist (MRA) that reduces the harmful effects of mineralocorticoid receptor (MR) overactivation. This medicine is mainly used to treat chronic kidney disease (CKD, stages 3 and 4 with proteinuria) associated with type 2 diabetes (T2D) in adult patients. What's the effect? What is the correct usage and dosage?

finerenone effects

Finerenone is a nonsteroidal selective antagonist of the mineralocorticoid receptor (MR), which is activated by aldosterone and cortisol and regulates gene transcription.

The FIDELIO-DKD study is a randomized, double-blind, placebo-controlled, parallel-controlled, multi-center, event-driven Phase III clinical study. The results of the study showed that compared with placebo, finerenone also significantly reduced the risk of key secondary endpoints, reducing the risk of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke or hospitalization for heart failure by 14% during a median follow-up time of 2.6 years.

Correct dosage of finerenone

The recommended starting dose of finerenone is 10 mg or 20 mg orally once daily, based on estimated glomerular filtration rate (eGFR) and serum potassium threshold.

Based on eGFR and serum potassium thresholds, after 4 weeks, finerenone dose was increased to a target dose of 20 mg once daily. Finerenone tablets can be taken with or without food. The dosage and duration of treatment with finerenone will vary depending on the patient's disease progression and physical condition. The actual dosage of finerenone can be adjusted according to the patient's physical condition and tolerance to the drug.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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