非奈利酮治疗哪种糖尿病,有什么效果？

(Finerenone) is a third-generation aldosterone receptor antagonist (MRA) developed by Bayer, Germany. Compared with the steroidal structures of first-generation spironolactone and second-generation eplerenone, the unique non-steroidal structure of fenelinone ensures high receptor selectivity while greatly avoiding the risk of adverse events caused by traditional steroidal MRA. So, what type of diabetes does fenelinone treat?

What kind of diabetes does Fenelidone treat?

On July 9, 2021, the U.S. Food and Drug Administration (FDA) approved fenelidone for marketing in the United States for the treatment of CKD with type 2 diabetes. In February 2021, the application for marketing of fenelidone film-coated tablets in my country has been accepted by the Drug Evaluation Center of the State Drug Administration. The drug’s latest phase II clinical trial (FIDELIO-DKD) further confirmed that fenelidone can bring dual heart and kidney benefits to patients with type 2 diabetic nephropathy, and has good safety profile.

What are the effects of fenelinone

In 2021, the cardiovascular outcomes part of the FIDELIO-DKD study was published, answering the question of the effect of fenelidone on T2DM with diabetes.

Impact of pure cardiovascular outcomes in patients with kidney disease (DKD) and those with and without a history of atherosclerotic cardiovascular disease (CVD)

Impact on prognosis, cardiovascular outcomes include cardiovascular death, myocardial infarction, stroke, or length of hospitalization for heart failure. The results showed that compared with placebo, fenelidone reduced the risk of composite cardiovascular outcomes by 14% (HR =0.86, P =0.034), and the presence of prior CVD disease did not affect this treatment effect.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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