达格列净和非奈利酮的区别？

On February 27, 2023, the Shanghai Pharmaceutical Centralized Tendering and Procurement Administration announced the latest list of "dual-channel" managed drugs, which included a total of 383 varieties, including sugammadex sodium injection, dapagliflozin tablets, tablets, etc., which also have the effect of lowering blood sugar and treating heart failure and chronic kidney disease. So, what is the difference between dapagliflozin tablets and fenelidone tablets?

The difference between dapagliflozin and fenelidone

The mechanisms of action are different. Dapagliflozin is a new type of SGLT2 inhibitor that can specifically inhibit the sodium-glucose co-transporter, thereby reducing the renal reabsorption of glucose in the body, causing the urine glucose concentration to increase to achieve the purpose of lowering blood sugar. However, long-term use of dapagliflozin can increase the risk of reproductive system infection in patients. Nonelidone is the first new type of selective oral non-steroidal mineralocorticoid receptor antagonist. It is used for the treatment of diabetic nephropathy, chronic kidney disease and end-stage renal disease. It can reduce proteinuria in patients.

Increase glomerular filtration rate.

How to choose between dapagliflozin and fenelidone

At a press conference announcing the success of the trial, someone asked the person in charge of Fenelidone Pharmaceuticals: How does your Fenelidone compare to Liflozin, which has also been successful in recent years? He replied: The two drugs have different mechanisms, which means they can be used at the same time. There is no need to differentiate between them. In the case where the curative effects can be superimposed, the necessity of distinguishing between superior and inferior is indeed smaller.

Therefore, there is no need for patients to distinguish or compare the efficacy of the two. In clinical practice, the choice of which drug to treat should not be entirely based on the efficacy or data. The doctor should judge the most suitable drug based on your physical condition and disease condition, which is truly beneficial to the patient himself.

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