托伐普坦片的用法用量是怎样的？长期服用有副作用吗？

Tolvaptan tablets, the substrate of P glycoprotein, are AVP receptor antagonists and were launched in the United States in 2009. Clinically, tolvaptan tablets are used to treat hyponatremia caused by congestive heart failure, liver cirrhosis, and syndrome of insufficient secretion of antidiuretic hormone. It is a drug with diuretic effect. Today, let’s learn more about the usage and dosage of the tablets. Are there any side effects of long-term use?

Tolvaptan tablets need to be taken under the guidance of a doctor. Patients need to follow the doctor's instructions for usage and dosage. The usual starting dose of the drug is 15mg, which can be taken before or after meals, once a day. If you need to increase the dose, increase the dose to 30 mg once a day at least 24 hours after taking the drug. Depending on serum sodium concentration, it can be increased to 60 mg once daily. Restriction of fluid intake during the first 24 hours of treatment should be avoided, and changes in serum electrolytes and blood volume should be monitored frequently during initial administration and dose increases. Patients are not allowed to change the dosage and usage on their own to avoid intolerance reactions and affect the original condition.

So, are there any side effects of long-term use of tolvaptan tablets?

Fatigue, constipation, thirst, dry mouth, frequent or polyuria, hyperglycemia, cirrhosis, nausea, heart failure, etc. Generally speaking, the safety of this drug is controllable and it is well tolerated. However, if the patient develops an intolerance reaction during medication, he or she should contact the doctor promptly and adopt a new treatment plan. Tolvaptan tablets can treat most cases of hyponatremia or liver cirrhosis, but patients with hypernatremia or allergies to this drug should try not to use it. Patients should read the instructions carefully before taking the medicine and use the medicine accordingly.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

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