使用托伐普坦片你必须要注意的事情

Since tolvaptan was approved for marketing by the U.S. Food and Drug Administration (FDA) in 2009, it has been widely used in the treatment of heart failure edema and cirrhosis ascites combined with hyponatremia. It has been approved in China for the treatment of heart failure, liver cirrhosis, dilutional hyponatremia, etc. For patients with renal insufficiency, high risk of renal damage, and combined with CKD and other kidney diseases, research shows that it may have a protective effect on renal function, reducing the occurrence and worsening probability of renal damage in patients, and may have long-term effects of improving renal function and prognosis, and reducing the number of hospitalizations. For patients with heart failure and CKD stages 4 and 5, the time to start dialysis can be extended.

But you must pay attention to the following things when using tolvaptan tablets:

Things you must pay attention to when using tolvaptan tablets: Correcting the serum concentration of hyponatremia too quickly (>12mEq/L/24 hours) carries the risk of osmotic demyelination syndrome, which can cause dysarthria, mutism, dysphagia, drowsiness, affective changes, spastic quadriplegia, seizures, coma and death. For patients prone to osmotic demyelination such as severe malnutrition, alcoholism, and advanced liver disease, it is recommended to slow down the correction of serum sodium.

Finally, the editor of Medical Companion Travel hopes that patients who are currently using tolvaptan tablets will not believe or spread rumors. There is currently a lot of unreliable information on the Internet that conveys wrong information to everyone. For example, increasing the dose of the drug can achieve double the therapeutic effect, or reducing the dose of the drug can avoid the occurrence of side effects. These are without any basis. Only by following the doctor's instructions can the effect of the drug itself be maximized.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.