托伐普坦说明书禁忌是什么,儿童用量是多少?

Tolvaptan is a specific drug for the treatment of hypersoluble and isosoluble hyponatremia. It is a vasopressin V2 receptor antagonist. It can increase the concentration of sodium ions in the plasma and help water be excreted from the urine. It is a drug with a very good diuretic effect. So, what are the contraindications in the instructions for tolvaptan, and what is the dosage for children?

What are the contraindications in the instructions for tolvaptan?

Although tolvaptan has a significant therapeutic effect, it is contraindicated in some patients. Patients who urgently need to quickly increase serum sodium concentration, patients who are insensitive to thirst or cannot respond normally to thirst, patients with hypovolemic hyponatremia, patients with anuria, patients with hypernatremia, and those who are allergic to any component of this product are contraindicated in tolvaptan. In addition, this product cannot be used in combination with strong CYP3A inhibitors. For more details, patients can read the drug instructions.

What is the dosage of tolvaptan for children?

The medication of tolvaptan in children is not yet clear. Medications for children should be selected for treatment. It is recommended that patients follow the doctor's advice. The common starting dose of tolvaptan for adults is 15 mg, once a day, before or after meals. After taking the drug for at least 24 hours, the dose can be increased to 30 mg once daily, and then to 60 mg once daily based on the maximum serum sodium concentration.

Changes in serum electrolytes and blood volume should be monitored frequently during initial administration and dose increase, and fluid restriction should be avoided during the first 24 hours of treatment. Patients taking this product should drink water when thirsty. Tolvaptan tablets are highly safe. Only a few patients will experience adverse reactions such as dry mouth, dizziness, hypotension and nausea after taking the drug, but they are not serious and patients can rest assured. The above is the information on the contraindications of tolvaptan and the dosage for children.

Note: The above information comes from the Internet and is compiled and edited by Medical Companion Travel (please correct me if there are any errors or omissions). It is only to provide information on the latest drugs on the market in the world and help Chinese patients understand the latest international new drug trends. It is only for internal discussion among medical staff and does not serve as any basis for medication. For specific medication guidelines, please consult the attending physician.

Recommended related articles: