Rapamune中文的说明书

Chinese instruction manual

[Drug name] Sirolimus (rapamin)

[Main Ingredients] The main ingredient is sirolimus. Chemical name: (3S, 6R, 7E, 9R, 10R, 12R, 14S, 15E, 17E, 19E, 21S, 23S, 26R, 27R, 34aS)-9, 10, 12, 13, 14, 21, 22, 23, 24, 25, 26, 27, 32, 33, 34, 34a-hexahydro-9, 27-dihydroxy-3-[(1R)-2-[(1S, [Properties] This product is a triangular white or off-white sugar-coated tablet)

[Indications/Function Indications] Suitable for patients undergoing kidney transplantation to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids.  

[Specification model] 1mg*10s

[Usage and Dosage] It is recommended to use it in combination with cyclosporine and corticosteroids. Take orally, once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients. The overall safety profile of patients taking Rapamune 2 mg daily was better than that of patients taking Rapamune 5 mg daily.  

[Adverse reactions] Very common (according to the frequency classification of the International Council of Medical Organizations, the incidence rate is >10%): lymphocele, peripheral edema, abdominal pain, diarrhea, hypokalemia, increased lactate dehydrogenase, acne, urinary tract infection; very common at higher doses: anemia, hypercholesterolemia, thrombocytopenia, hypertriesteremia (hyperlipidemia). Store in a cool, dry, dark environment.  

[Contraindications] It is prohibited to be used by patients who are allergic to sirolimus, derivatives of sirolimus, or any ingredients in the oral solution of this drug, as well as pregnant and lactating women. 

[Precautions] Grapefruit juice can slow down the metabolism of this drug regulated by CYP3A4, so it cannot be used for administration or dilution of this drug. It is recommended to take sirolimus 4 hours after taking cyclosporine oral solution (modified version) and/or cyclosporine capsules (modified version).   

The above is the instruction manual in Chinese. Please read the instructions carefully and follow your doctor's instructions.