Rapamune国内什么时候上市？

Rapamin () is a nitrogen-containing macrolide microbial metabolite. They have a special structural group, that is, the lactone ring contains 1 molecule of non-protein amino acid - pipecolic acid. Through the pipecoyl group, it interacts with FKBPs (FK506 bingding proteins), a type of intracellular immunophilin with prolyl cis-trans isomerase activity, to form a complex. It acts on different targets in cells and exerts a variety of different biological functions. This type of compound has a wide range of biological activities. In addition to its antifungal activity, Rapamune has been clinically used as an anti-rejection drug for organ transplantation, a vasodilator stent coating drug, a targeted anti-tumor drug, and an inflammation treatment drug. At the same time, this type of compound also has the potential to treat stroke, neurodegenerative diseases, Parkinson's syndrome, Alzheimer's disease, etc. Harrison et al. reported in Nature magazine in July 2009 that Rapamune can extend the lifespan of aging mammalian mice, which immediately aroused widespread attention and high interest among scientists from all over the world. The American "Science" magazine selected this research result as one of the top ten scientific advances of the year. 

Rapamune is a drug manufactured by Pfizer of the United States. Rapamune oral solution is a new generation of immunosuppressant following the advent of cyclosporine A, mycophenolate mofetil and tacrolimus. It was launched in the United States and Europe in 1999 and in China at the end of 2003. Because it has low nephrotoxicity, it can maintain long-term stability of renal function, and it can also reduce the incidence of tumors in transplant patients while suppressing immunity. It is generally believed that rapamycin () binds to FKBP12, and the RAPA-FKBP12 complex binds to the mammalian target of rapamycin (mTOR), inhibiting the proliferation of T lymphocytes and B lymphocytes caused by various stimuli, causing cells to stay in the late Gl phase of the cell cycle, and preventing these cells from entering the S phase.