雷帕鸣治疗效果如何？

How effective is the treatment with (Rapamune)? To explore the clinical efficacy and safety of Rapamune in kidney transplantation. Methods A total of 23 patients with cadaveric kidney transplantation from our hospital were given triple immunosuppressive therapy with this product combined with cyclosporine and glucocorticoids. Start taking this product within 48 hours after transplantation, with a loading dose of 6 mg and a maintenance dose of 2 mg.

Results: 22 patients completed 6-12 months of follow-up. The incidence rates of acute rejection (AR) at 6 and 12 months were 13.6% (3 cases/22 cases) and 15.8% (3 cases/19 cases) respectively. AR patients were reversed after methylprednisolone pulse treatment and continued to be followed up for more than half a year. No recurrence of AR was found. The main adverse reaction was hyperlipidemia (56.5%, 13 cases/23 cases). After reducing the dosage of this product or applying lipid-lowering drugs, the patient's blood lipids dropped to normal or slightly higher than normal levels. Graft vascular disease and cardiovascular complications have not increased since follow-up.

In cells, rapamune binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian Rapamune BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from G1 to S phase in the cell cycle. Rapamune tablets are oral medications and are recommended to be taken once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose.

Rapamune combined with cyclosporine and glucocorticoids can reduce the incidence of AR after kidney transplantation, and its long-term efficacy requires further observation and research.

The above is the effect of Rapamune provided to you by our Medical Companion Travel Overseas Medical Consulting Service Company. From this point of view, the effect of Rapamune in treating kidney transplantation is still worthy of recognition.