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Sirolimus tablets () are suitable for patients receiving kidney transplants to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids. Very common (incidence >10% according to the International Council of Medical Organization frequency classification): lymphocele, peripheral edema, abdominal pain, diarrhea, hypokalemia, increased lactate dehydrogenase, acne, urinary tract infection; very common at higher doses: anemia, hypercholesterolemia, thrombocytopenia, hypertriesteremia (hyperlipidemia). Store in a cool, dry, dark environment. So what is the usage and dosage of sirolimus tablets? Many patients don’t know how to use sirolimus tablets. Let’s learn about it together.

Sirolimus is recommended for use in combination with cyclosporine and corticosteroids. Take orally, once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day. Although the loading dose of 15 mg and the maintenance dose of 5 mg/day used in clinical trials are safe and effective, the therapeutic benefits of doses above 2 mg are unclear for kidney transplant patients. The overall safety profile of patients taking 2 mg of sirolimus tablets daily was better than that of patients taking 5 mg sirolimus tablets daily. 

Compared with azathioprine and placebo, Rapamune significantly reduced the incidence of treatment failure at the 2 mg/d and 5 mg/d dose levels of sirolimus tablets 6 months after transplantation.

The above is the usage and dosage of sirolimus tablets () provided by our Medical Companion Travel Overseas Medical Consulting Service Company. If you have other questions, please consult the Medical Companion Travel Service.