雷帕鸣中国上市了没？

Is it listed in China? Sirolimus is a drug manufactured by Pfizer of the United States. So is sirolimus on the market? Sirolimus oral solution is a new generation of immunosuppressant following the advent of cyclosporine A, mycophenolate mofetil and tacrolimus. It was launched in the United States and Europe in 1999 and in China at the end of 2003. Because it has low nephrotoxicity, it can maintain long-term stability of renal function, and it can also reduce the incidence of tumors in transplant patients while suppressing immunity. It is generally believed that rapamycin (sirolimus) binds to FKBP12, and the RAPA-FKBP12 complex binds to the mammalian target of rapamycin (mTOR), inhibiting the proliferation of T lymphocytes and B lymphocytes caused by various stimuli, causing cells to stay in the late Gl phase of the cell cycle, and preventing these cells from entering the S phase.

To explore the clinical efficacy and safety of sirolimus in renal transplantation. Methods A total of 23 patients with cadaveric kidney transplantation from our hospital were given triple immunosuppressive therapy with this product combined with cyclosporine and glucocorticoids. Start taking this product within 48 hours after transplantation, with a loading dose of 6 mg and a maintenance dose of 2 mg.

Results: 22 patients completed 6-12 months of follow-up. The incidence rates of acute rejection (AR) at 6 and 12 months were 13.6% (3 cases/22 cases) and 15.8% (3 cases/19 cases) respectively. AR patients were reversed after pulse treatment with methylprednisolone and continued to be followed up for more than half a year. No recurrence of AR was found. The main adverse reaction was hyperlipidemia (56.5%, 13 cases/23 cases). After reducing the dosage of this product or applying lipid-lowering drugs, the patient's blood lipids dropped to normal or slightly higher than normal levels. Graft vascular disease and cardiovascular complications have not increased since follow-up.

Sirolimus is currently on the market in my country. Patients can buy it at pharmacies in major hospitals. Our medical companions will also buy sirolimus at an affordable price and with ideal results. It can also be delivered directly to your home, so patients can buy it with confidence.