雷帕鸣国内怎么买？

For patients undergoing kidney transplantation, it is recommended to be used in combination with cyclosporine and corticosteroids to prevent organ rejection. Rapamin inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, rapamycin binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian Siros BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from G1 to S phase in the cell cycle.

The safety and efficacy of rapamycin in children under 13 years of age have not been established. If used in children under 13 years of age, it is recommended to monitor the whole blood trough concentration of rapamycin.

The safety and efficacy of rapamycin have been studied in children 13 years of age and older who are at low to moderate immunological risk. The use of rapamycin in this population of children 13 years of age and older has been supported by adequate, well-controlled clinical trials in adults taking rapamycin oral solution. Pharmacokinetic data in pediatric transplant patients were specifically analyzed in these trials.  

Rapamycin was first marketed in the United States with FDA approval in 1999. It has been marketed in the United Kingdom, Germany, Denmark and other countries, and is mainly used for kidney transplant rejection. With the continuous improvement of rapamycin production technology and the increase in output in my country, rapamycin is expected to become a high-speed growing variety in China and meet the needs of the world market. Its market development space is huge. Rapamycin is a new type of immunosuppressant and a multi-purpose drug. In recent years, with the rapid development of organ transplant surgery, the demand for immunosuppressants has greatly increased in terms of dosage and type. As a new generation of immunosuppressants, rapamycin not only has important medical value, but its derivatives also have broad prospects in the treatment of cancer, autoimmune diseases and Alzheimer's disease, and have been developed and applied especially in anti-cancer drugs.

Clinical research on rapamycin derivatives has been carried out abroad for many years, and the research prospects are very broad. The rapamycin derivative temsirolimus was approved by the FDA in 2007 for anti-kidney cancer treatment. In 2009, Novartis' everolimus was approved by the FDA for the treatment of kidney cancer, pancreatic cancer, brain cancer and other tumors. In addition, new derivatives of rapamycin are also emerging. For example, Biolimus, deforolimus, Zotarolimus, Radiforolimus, Deforolimus, etc.

If patients want to purchase medicines, they can go to the pharmacies of major domestic hospitals with a doctor's advice. Another way is to choose regular domestic medical service institutions to purchase medicines, such as Medical Companion Travel. We will provide you with a fast and convenient medicine purchase channel, and the medicines will be delivered directly to your home, ensuring the authenticity of the source.