雷帕鸣医保后的价格是多少？

For patients undergoing kidney transplantation, it is recommended to be used in combination with cyclosporine and corticosteroids to prevent organ rejection. Rapamin inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies. In cells, rapamycin binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian Siros BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from G1 to S phase in the cell cycle.

The safety and efficacy of rapamycin in children under 13 years of age have not been established. If used in children under 13 years of age, it is recommended to monitor the whole blood trough concentration of rapamycin.

At the same time, this type of compound also has the potential to treat stroke, neurodegenerative diseases, Parkinson's syndrome, Alzheimer's disease, etc. Harrison et al. reported in Nature magazine in July 2009 that rapamycin can extend the lifespan of aging mammalian mice, which immediately aroused widespread attention and high interest among scientists from all over the world. The American "Science" magazine selected this research result as one of the top ten scientific advances of the year.

Because rapamin has low nephrotoxicity, it can maintain long-term stability of renal function, and it can also reduce the incidence of tumors in transplant patients while suppressing immunity. It is generally believed that rapamycin binds to FKBP12, and the RAPA-FKBP12 complex binds to the mammalian target of rapamycin (mTOR), inhibiting the proliferation of T lymphocytes and B lymphocytes caused by various stimuli, causing cells to stay in the late G1 phase of the cell cycle, and preventing these cells from entering the S phase.

So what is the price of Leipa Ming after medical insurance?

Medically insured drugs refer to drugs that are necessary to ensure the clinical treatment of employees and are included in the scope of basic medical insurance benefits. They are divided into Category A and Category B. Since sirolimus cannot be found in the "Basic Medical Insurance Drug Catalog", (sirolimus) is not a medically insured drug, so there is no way to talk about issues related to medical insurance. Patients need to pay out of their own pockets to purchase. The editor recommends that everyone go to a regular hospital to purchase.