sirolimus治什么？

What conditions is (Rapamune) used to treat? Let’s find out together below. Sirolimus (Rapamune) was approved by the FDA on May 30, 2007 for the treatment of advanced kidney disease and kidney transplantation. It has entered clinical phase 4 for the treatment of mantle cell lymphoma.

As mentioned in the efficacy and role of sirolimus (Rapamune), sirolimus (Rapamune) is suitable for patients receiving kidney transplants to prevent organ rejection. Recommended for use in combination with cyclosporine and corticosteroids. Sirolimus, the main component of sirolimus (Rapamune), inhibits the activation and proliferation of T lymphocytes stimulated by antigens and cytokines (interleukins IL-2, IL-4 and IL-15). It also inhibits the production of antibodies.

In cells, sirolimus (Rapamune) binds to the immunophilin, FK-binding protein-12 (FKBP-12), to generate the FKBP-12 immunosuppressive complex. This complex binds to the mammalian sirolimus BA molecule (mTOR, a key regulatory kinase) and inhibits its activity, thereby inhibiting the progression from the G1 phase to the S phase in the cell cycle.

Sirolimus (Rapamune) is an oral medication that is recommended to be taken once daily. It should be started as soon as possible after transplantation. For new transplant recipients, the loading dose that should be taken for the first time is three times the maintenance dose. The recommended loading dose for kidney transplant patients is 6 mg and the maintenance dose is 2 mg/day.

Adverse reactions of sirolimus (Rapamune) are common (incidence >10% according to International Council of Medical Organization frequency classification): lymphocele, peripheral edema, abdominal pain, diarrhea, hypokalemia, increased lactate dehydrogenase, acne, urinary tract infection; common at higher doses: anemia, hypercholesterolemia, thrombocytopenia, hypertriesteremia (hyperlipidemia). Store in a cool, dry, dark environment.

When taking sirolimus (Rapamune), patients should be careful not to use grapefruit juice to deliver or dilute sirolimus (Rapamune). Because grapefruit juice can slow down the metabolism of sirolimus tablets and reduce its efficacy.

The above is about the indications. I hope it can help everyone.